Evidence map›Paper›PMID 39572569›Full record

ArticleNature communications2024

Calcium nanoparticles target and activate T cells to enhance anti-tumor function.

Wei Yang, Zhizi Feng, Xinning Lai, Jianwen Li, Zhengwei Cao, Fangchao Jiang, Fanghui Chen, Shuyue Zhan, Feng Kong, Li Yang and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Exercise and CD8Journal of molecular medicine (Berlin, Germany) · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Targeted nano-drug delivery systems for tumor immunotherapy.Journal of pharmaceutical analysis · 2026
    Review
  13. Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wei YangDepartment of Chemistry, University of Georgia, Athens, GA, USA.ORCID 0000-0001-6905-2296
Zhizi FengDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Xinning LaiDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Jianwen LiDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Zhengwei CaoDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Fangchao JiangDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Fanghui ChenDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Shuyue ZhanDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Feng KongDepartment of Plant Pathology, University of Georgia, Athens, GA, USA.ORCID 0000-0002-2700-8307
Li YangDepartment of Plant Pathology, University of Georgia, Athens, GA, USA.
Yong TengDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-1856-7289
Wendy T WatfordDepartment of Infectious Diseases, University of Georgia, Athens, GA, USA.
Gang ZhouGeorgia Cancer Center, Department of Medicine, Medical College of Georgia, Augusta, GA, USA. gzhou@augusta.edu.ORCID 0000-0001-8967-114X
Jin XieDepartment of Chemistry, University of Georgia, Athens, GA, USA. jinxie@uga.edu.ORCID 0000-0002-8915-6233

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
Persistent STAT5 signaling in polyfunctional CD4 T cells and its application in adoptive T cell therapyR01CA264983 · NCI · AUGUSTA UNIVERSITY · PI SHI, HUIDONG, ZHOU, GANG · 2021 to 2025
$2.6M
The development of novel radiation-sensitizer based on ultra-small carbon dotsR01CA247769 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO, XIE, JIN · 2020 to 2024
$2.5M
Exploiting the immunomodulatory effects of sulindac and novel non-COX inhibitory derivatives for cancer treatmentR01CA238514 · NCI · AUGUSTA UNIVERSITY · PI PIAZZA, GARY A, ZHOU, GANG · 2020 to 2024
$2.1M
Development of a novel biodegradable inorganic nanoparticle therapeutic for cancerR01CA257851 · NCI · UNIVERSITY OF GEORGIA · PI KIM, WILLIAM Y., LI, ZIBO · 2021 to 2024
$2.1M
ATAD3A as a Novel Target in Head and Neck CancerR01DE028351 · NIDCR · EMORY UNIVERSITY · PI TENG, YONG · 2019 to 2023
$1.9M
Dissect the Timing Mechanism for Immune Maturation in PlantsR35GM143067 · NIGMS · UNIVERSITY OF GEORGIA · PI Li Yang · 2021 to 2026
$1.7M
Emory University | Winship Cancer Institute (Winship Cancer Institute of Emory University) P30CA138292NCI NIH HHS P30 CA138292NCI NIH HHS R01 CA238514NCI NIH HHS R01 CA247769NCI NIH HHS R01 CA257851NCI NIH HHS R01 CA264983NIDCR NIH HHS R01 DE028351NIGMS NIH HHS R35 GM143067United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP) HT94252410734U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA247769U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA257851U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE028351U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM143067
6 · The paper itself

Abstract

Calcium signaling plays a crucial role in the activation of T lymphocytes. However, modulating calcium levels to control T cell activation in vivo remains a challenge. In this study, we investigate T cell activation using 12-myristate 13-acetate (PMA)-encapsulated CaCO

Indexed as

CalciumCalcium CarbonateLymphocyte ActivationNanoparticlesAnimalsCalcium SignalingCell Line, TumorCell ProliferationFemaleHumansMiceMice, Inbred C57BLNFATC Transcription FactorsNF-kappa BProgrammed Cell Death 1 ReceptorT-LymphocytesCalciumCalcium CarbonateNFATC Transcription FactorsNF-kappa BProgrammed Cell Death 1 Receptor

Identifiers

PMID39572569
PMCPMC11582315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.