ArticleNature communications2024
Metabolomic and genomic prediction of common diseases in 700,217 participants in three national biobanks.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- MetaboHealth and Metabolic Vulnerability Index as Risk Factors for Cardio-Renal-Metabolic Multimorbidity: A Large-Scale Prospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk.BMC medicine · 2026Article
- Metabolomic Profiles in Down Syndrome: A Scoping Review of Convergent and Context-Dependent Patterns.Journal of intellectual disability research : JIDR · 2026Article
- Circulating metabolites in plasma reveal potential target of lung cancer prevention: insights from fatty acids pathway.Nutrition journal · 2026Article
- Alterations of Plasma Metabolites Associated with Sickle Cell Trait.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Association of Genetic Liability to Psychiatric Disorders with Peripheral Metabolic Dysregulation.medRxiv : the preprint server for health sciences · 2026Article
- Data-driven prioritization of high-risk individuals for weight loss interventions.Nature medicine · 2026Article
- A lipidomics roadmap: from basic research to societal challenges.Nature communications · 2026Review
- Leveraging Multiomic Signatures to Predict Body Composition.Advances in nutrition (Bethesda, Md.) · 2026Review
- Metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Occupation Associated with Altered Steroid Hormone Metabolism in Men: A Cross-Sectional Metabolome-Wide Association Study.Research square · 2026Article
- Lifestyles, metabolome and diabetic kidney disease: a cohort study.QJM : monthly journal of the Association of Physicians · 2026Article
- Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study.PLoS medicine · 2026Article
- Multiomics: the intersection of personalized nutrition in cardiometabolic diseases.Journal of translational medicine · 2026Review
- AI-based multiomics profiling reveals complementary omics contributions to personalized prediction of cardiovascular disease.Nature communications · 2026Article
- Prediction of Episodic Memory With Multiomics Scores.Biological psychiatry global open science · 2026Article
- Deep sequence learning with multi-task supervision for scalable population health monitoring.Frontiers in public health · 2026Article
- Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction.European heart journal · 2025Article
- Shared genetic architecture between anorexia nervosa and metabolomic biomarkers suggest underlying causal pathways.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying individuals at high risk of chronic diseases via easily measured biomarkers could enhance efforts to prevent avoidable illness and death. Using 'omic data can stratify risk for many diseases simultaneously from a single measurement that captures multiple molecular predictors of risk. Here we present nuclear magnetic resonance metabolomics in blood samples from 700,217 participants in three national biobanks. We built metabolomic scores that identify high-risk groups for diseases that cause the most morbidity in high-income countries and show consistent cross-biobank replication of the relative risk of disease for these groups. We show that these metabolomic scores are more strongly associated with disease onset than polygenic scores for most of these diseases. In a subset of 18,709 individuals with metabolomic biomarkers measured at two time points we show that people whose scores change have different risk of disease, suggesting that repeat measurements capture changes both to health status and disease risk possibly due to treatment, lifestyle changes or other factors. Lastly, we assessed the incremental predictive value of metabolomic scores over existing clinical risk scores for multiple diseases and found modest improvements in discrimination for several diseases whose clinical utility, while promising, remains to be determined.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.