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ArticleDermatology and therapy2024

Characteristics of Patients with Generalized Pustular Psoriasis: A Report of the Polish Generalized Pustular Psoriasis Group.

Marta Kołt-Kamińska, Luiza Marek-Józefowicz, Piotr Krajewski, Julia Nowowiejska, Aleksandra Siekierko, Ewa Duchnik, Katarzyna Jóźwicka, Magdalena Kiedrowicz, Mateusz Mleczko, Hubert Arasiewicz and 12 more

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In one paragraph

Article in Dermatology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Marta Kołt-KamińskaDepartment of Dermatology, Institute of Medical Sciences, Medical College of the University of Rzeszów, Rzeszów, Poland.
Luiza Marek-JózefowiczDepartment of Dermatology and Venerology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Ludwik Rydygier, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.
Piotr KrajewskiDepartment of Dermatology, Venerology and Allergology, Wroclaw Medical University, Wrocław, Poland.
Julia NowowiejskaDepartment of Dermatology and Venereology, Medical University of Bialystok, Białystok, Poland.
Aleksandra SiekierkoDepartment of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Łódź, Poland.
Ewa DuchnikDepartment of Dermatology and Venereology, Pomeranian Medical University, Police, Poland.
Katarzyna JóźwickaDepartment and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Magdalena KiedrowiczDepartment of Dermatology and Venereology, Pomeranian Medical University, Police, Poland.
Mateusz MleczkoDepartment of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
Hubert ArasiewiczDepartment of Dermatology and Vascular Anomalies, John Paul II Centre of Paediatrics, Sosnowiec, Poland.
Monika KucharczykDepartment of Dermatology, Jan Kochanowski University of Kielce, Kielce, Poland.
Witold OwczarekDepartment of Dermatology, Military Institute of Medicine, Warsaw, Poland.
Irena WaleckaDepartment of Dermatology, Centre of Postgraduate Medical Education, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland.
Jacek C SzepietowskiDepartment of Dermatology, Venerology and Allergology, Wroclaw Medical University, Wrocław, Poland.
Iwona FlisiakDepartment of Dermatology and Venereology, Medical University of Bialystok, Białystok, Poland.
Aleksandra LesiakDepartment of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Łódź, Poland.
Joanna NarbuttDepartment of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Łódź, Poland.
Mariola MarchlewiczDepartment of Dermatology and Venereology, Pomeranian Medical University, Police, Poland.
Agnieszka Owczarczyk-SaczonekDepartment and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Dorota KrasowskaDepartment of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
Beata KręciszDepartment of Dermatology, Jan Kochanowski University of Kielce, Kielce, Poland.
Adam ReichDepartment of Dermatology, Institute of Medical Sciences, Medical College of the University of Rzeszów, Rzeszów, Poland. adamandrzejreich@gmail.com.ORCID http://orcid.org/0000-0002-5573-1754

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionData on generalized pustular psoriasis (GPP) in Poland are limited. Therefore, this study aimed to evaluate the demographic and clinical characteristics of Polish patients with GPP. In addition, the effect of the frequency of disease flares and the concomitant presence of psoriasis vulgaris (PV) on patient characteristics was evaluated.

methodsIn this retrospective study, medical records of patients hospitalized for GPP in dermatology departments of the Polish Generalized Pustular Psoriasis Group were analyzed.

resultsA total of 90 patients from 14 dermatology centers were included. The median age of patients was 59 (range, 5-85) years, and most patients were female (68.9%). The most common comorbidity was hypertension (43.3%), followed by cardiovascular diseases, diabetes, and hyperlipidemia. The median duration of GPP was 3 years, and the median number of flares was 2. Hospitalization was required in 67% of flares. The main triggering factors were drugs (20.5%) and infections (19.3%). Women and men with GPP differed in terms of age (p < 0.01), distribution of comorbidities, and selected triggering factors (stress: p < 0.05). Almost 25% of patients experienced more than one flare per year. Patients with different frequency of flares did not differ significantly in age, sex distribution, or comorbidities, but those with a higher frequency of flares had a shorter disease duration (median: 0.6 vs. 4.0 years; p < 0.01). In 59.1% of patients, GPP was accompanied by PV. Patients with GPP and PV were younger than those with GPP alone (median: 48.0 vs. 66.0 years; p < 0.01).

conclusionsIn this study, the general demographic and clinical characteristics of patients with GPP were consistent with those described in other studies. However, a high rate of flares requiring hospitalization and a significant percentage of patients experiencing more than one flare per year indicate the unmet need in the management of patients with GPP.

Indexed as

FlaresGeneralized pustular psoriasisPsoriasis vulgarisTreatment

Identifiers

PMID39572507
PMCPMC11604985

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