Evidence map›Paper›PMID 39572490›Full record

ArticleBulletin of experimental biology and medicine2024

Activity of NAD(P)-Dependent Dehydrogenases of Ovarian Vein Lymphocytes in Women with Pelvic Varicose Veins.

A A Semendyaev, M A Darenskaya, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, L I Kolesnikova

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

A A SemendyaevIrkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia.
M A DarenskayaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia. marina_darenskaya@inbox.ru.
D A StupinIrkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia.
S I KolesnikovScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
N V SemenovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
D V TukhievaIrkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia.
L I KolesnikovaScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The activities of NAD- and NADP-dependent isocitrate dehydrogenases (NAD-ICDH and NADP-ICDH), NAD- and NADP-dependent glutamate dehydrogenases (NAD-GDH and NADP-GDH), and NAD- and NADP-dependent malate dehydrogenases (NAD-MDH and NADP-MDH) in ovarian veins lymphocytes in 183 women of reproductive age with pelvic varicose veins (PVV) and 30 women in the control group were determined. The indicators of intracellular enzymatic activity showed multidirectional changes with increasing severity of the disease. Compared to the control group, women with stage II of PVV had higher median values for lactate dehydrogenase (16.69), NAD-GDH (39.48), NADP-GDH (7.48), NADP-MDH (9.06) and lower values of NAD-ICDH (65.41). Women with stage III of PVV had lower median values for succinate dehydrogenase (9.27), NAD-MDH (26.19), and higher values for glucose-6-phosphate dehydrogenase (8.62), lactate dehydrogenase (24.67), NAD-GDH (63.81), NADP-MDH (21.05) compared to the control group. Studying the activity of NAD(P)-dependent dehydrogenases in lymphocytes at the local level during PVV allows us to evaluate the intensity and dynamics of local varicose veins progression, as well as to optimize its correction.

Indexed as

LymphocytesOvaryVaricose VeinsAdultCase-Control StudiesFemaleGlucosephosphate DehydrogenaseGlutamate DehydrogenaseHumansIsocitrate DehydrogenaseL-Lactate DehydrogenaseMalate DehydrogenaseMiddle AgedPelvisSuccinate DehydrogenaseVeinsGlucosephosphate DehydrogenaseGlutamate DehydrogenaseIsocitrate DehydrogenaseL-Lactate DehydrogenaseMalate DehydrogenaseSuccinate DehydrogenaselymphocytesNAD(P)-dependent dehydrogenasesovarian veinspelvic varicose veinswomen

Identifiers

PMID39572490

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.