Evidence map›Paper›PMID 39572476›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2025

Influence of Agaricus blazei Murill polysaccharides on synthesis, stabilization, acute toxicity and antifungal activity of copper (II) oxide nanoparticles.

Álamo Lourenço de Souza, Matheus da Silva Campelo, Gabriel de Sousa Mesquita, Augusto Feynman Dias Nobre, Vitória Maria de Freitas Franco, Antônio César Honorato Barreto, Jeanlex Soares de Sousa, José Eduardo Ribeiro Honório Júnior, Raimunda Sâmia Nogueira Brilhante, Nágila Maria Pontes Silva Ricardo and 2 more

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Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

12 authors.

Álamo Lourenço de SouzaDepartment of Organic and Inorganic Chemistry, Polymers and Materials Innovation Laboratory, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60440-900, Brazil.
Matheus da Silva CampeloDepartment of Organic and Inorganic Chemistry, Polymers and Materials Innovation Laboratory, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60440-900, Brazil.
Gabriel de Sousa MesquitaDepartment of Organic and Inorganic Chemistry, Polymers and Materials Innovation Laboratory, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60440-900, Brazil.
Augusto Feynman Dias NobreDepartment of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Federal University of Ceará, Porangabuçu Campus, Fortaleza, CE, 60425-540, Brazil.
Vitória Maria de Freitas FrancoZebrafish Laboratory, Christus University Center, Benfica Campus, Fortaleza, CE, 60015-061, Brazil.
Antônio César Honorato BarretoDepartment of Physics, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60455-970, Brazil.
Jeanlex Soares de SousaDepartment of Physics, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60455-970, Brazil.
José Eduardo Ribeiro Honório JúniorZebrafish Laboratory, Christus University Center, Benfica Campus, Fortaleza, CE, 60015-061, Brazil.
Raimunda Sâmia Nogueira BrilhanteDepartment of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Federal University of Ceará, Porangabuçu Campus, Fortaleza, CE, 60425-540, Brazil.
Nágila Maria Pontes Silva RicardoDepartment of Organic and Inorganic Chemistry, Polymers and Materials Innovation Laboratory, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60440-900, Brazil.
Sandra de Aguiar SoaresDepartment of Organic and Inorganic Chemistry, Polymers and Materials Innovation Laboratory, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60440-900, Brazil. sas@ufc.br.
Maria Elenir Nobre Pinho RibeiroDepartment of Organic and Inorganic Chemistry, Polymers and Materials Innovation Laboratory, Federal University of Ceara, Pici Campus, Fortaleza, CE, 60440-900, Brazil. elenir.ribeiro@ufc.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In general, nanomaterials tend to have better physical, chemical and biological properties than conventional materials. Furthermore, the polysaccharides from Agaricus blazei Murill mushroom have several pharmacological properties, in addition to low cytotoxicity and high biocompatibility. This work sought to merge the properties of CuO nanoparticles and Agaricus blazei Murill polysaccharides through syntheses and coatings with the aim of evaluating their toxicity in adult zebrafish and antifungal activity against C. albicans and C. parapsilosis. The nanoparticles were synthesized using the coprecipitation method and subsequently characterized in terms of their physicochemical properties using spectroscopic and thermoanalytical techniques. Furthermore, their composition was determined by X-Ray Diffraction and their morphology was studied using different microscopic techniques. CuO nanoparticles coated with Agaricus blazei Murill polysaccharides showed smaller particle size. Dispersions of nanoparticles coated with the polysaccharides were found to be more stable than their uncoated counterparts. The nanoparticles also showed antifungal activity against Candida sp. strains, with MIC

Indexed as

AgaricusAntifungal AgentsCopperMetal NanoparticlesPolysaccharidesAnimalsCandida albicansCandida parapsilosisMicrobial Sensitivity TestsParticle SizeZebrafishAntifungal AgentsCoppercuprous oxidePolysaccharidesAgaricus brasiliensisBiopolymerCandida sp.Metal nanoparticlesNanoparticle coating

Identifiers

PMID39572476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.