Evidence map›Paper›PMID 39572465›Full record

ArticleAesthetic plastic surgery2025

Sodium Carboxymethylcellulose Serves as Sustained-Release Agents for Providing Analgesia at the Donor Site After Costal Cartilage Harvesting in Ear Reconstruction.

Yiwen Deng, Ben Wang, Haiyue Jiang, Wenkang Luan, Bo Pan, Chuan Li

Abstract read
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In one paragraph

Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yiwen Deng *Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, P.R. China.
Ben Wang *Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, P.R. China.
Haiyue JiangDepartment of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, P.R. China.
Wenkang LuanDepartment of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, P.R. China.
Bo PanDepartment of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, P.R. China.
Chuan LiDepartment of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, P.R. China. lichuan_pumc@163.com.

Funding

Plastic Medicine Research Fund of Chinese Academy of Medical Sciences 2024-ZX-2-03
6 · The paper itself

Abstract

backgroundThe postoperative pain experienced at the donor site following ear reconstruction using autologous costal cartilage significantly impacts patients' quality of life. Sodium carboxymethylcellulose demonstrates a favorable sustained release property, and its potential to prolong the analgesic effect of ropivacaine remains unexplored. The present study aimed to investigate the analgesic efficacy of ropivacaine gel formulated with sodium carboxymethylcellulose as a sustained-release agent on the donor site of costal cartilage.

methodA retrospective analysis was conducted on a total of 75 patients who underwent costal cartilage ear reconstruction. The patients were divided into three groups based on the different analgesic methods applied to the cartilage donor site: ropivacaine solution group, ropivacaine gel group, and ropivacaine solution combined with gel group. The visual analog scale (VAS) and patient-controlled analgesia (PCA) were used to evaluate the severity of chest pain.

resultsThe study included a total of 60 patients undergoing ear reconstruction, with 20 patients in each group. The VAS chest pain score and the frequency of PCA application were lower in both the ropivacaine gel group and the ropivacaine solution combined with gel group compared to the ropivacaine solution group. There was no significant difference observed between the ropivacaine gel group and the ropivacaine solution combined with gel group.

conclusionThe utilization of sodium carboxymethyl cellulose as a sustained-release agent in the formulation of ropivacaine gel has been found to effectively prolong the duration of pain relief and alleviate postoperative discomfort at the donor site following ear reconstruction with costal cartilage harvesting. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Carboxymethylcellulose SodiumCostal CartilagePlastic Surgery ProceduresPostoperative PainRopivacaineTissue and Organ HarvestingAdultAnalgesia, Patient-ControlledAnesthetics, LocalCohort StudiesDelayed-Action PreparationsFemaleFollow-Up StudiesHumansMaleMiddle AgedAnesthetics, LocalCarboxymethylcellulose SodiumDelayed-Action PreparationsRopivacaineCostal cartilageEar reconstructionPostoperative painRopivacaine hydrogelSodium carboxymethylcellulose

Identifiers

PMID39572465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.