Evidence map›Paper›PMID 39572449›Full record

ArticleEuropean radiology2025

Cryoablation for treatment of peripheral lung metastases from colorectal cancer: a bicenter retrospective study.

Jean Izaaryene, Rémi Grange, Vincent Habouzit, Sylvain Grange, Bastien Orsini, Michael Dassa, Nassima Daidj, Louis Thierry, Marjorie Ferre, Jean Marc Phelip and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jean IzaaryeneInterventional Radiology Department, Institut Paoli Calmettes, Aix Marseille University, 232 Boulevard Sainte Marguerite, 13009, Marseille, France. izaaryenej@ipc.unicancer.fr.ORCID http://orcid.org/0000-0002-7948-4225
Rémi GrangeDepartment of Interventional Radiology, University Hospital of Saint-Etienne, University Hospital of Saint-Etienne, Avenue Albert Raimond, 42270, Saint-Priest-en-Jarez, France.
Vincent HabouzitDepartment of Interventional Radiology, University Hospital of Saint-Etienne, University Hospital of Saint-Etienne, Avenue Albert Raimond, 42270, Saint-Priest-en-Jarez, France.
Sylvain GrangeDepartment of Interventional Radiology, University Hospital of Saint-Etienne, University Hospital of Saint-Etienne, Avenue Albert Raimond, 42270, Saint-Priest-en-Jarez, France.
Bastien OrsiniDepartment of Thoracic Surgery, Clairval Private Hospital, Ramsay Générale de Santé, Marseille, France.
Michael DassaInterventional Radiology Department, Institut Paoli Calmettes, Aix Marseille University, 232 Boulevard Sainte Marguerite, 13009, Marseille, France.
Nassima DaidjInterventional Radiology Department, Institut Paoli Calmettes, Aix Marseille University, 232 Boulevard Sainte Marguerite, 13009, Marseille, France.
Louis ThierryInterventional Radiology Department, Institut Paoli Calmettes, Aix Marseille University, 232 Boulevard Sainte Marguerite, 13009, Marseille, France.
Marjorie FerreInterventional Radiology Department, Institut Paoli Calmettes, Aix Marseille University, 232 Boulevard Sainte Marguerite, 13009, Marseille, France.
Jean Marc PhelipDepartment of Interventional Radiology, University Hospital of Saint-Etienne, University Hospital of Saint-Etienne, Avenue Albert Raimond, 42270, Saint-Priest-en-Jarez, France.
Bernard LelongSurgery Department Institut Paoli Calmettes, Aix Marseille University, 232 Boulevard Sainte Marguerite, 13009, Marseille, France.
Cécile De ChaisemartinSurgery Department Institut Paoli Calmettes, Aix Marseille University, 232 Boulevard Sainte Marguerite, 13009, Marseille, France.
Emmanuel MitryOncology Department, Institut Paoli Calmettes, 232 Boulevard Sainte Marguerite, 13009, Marseille, France.
Gilles PianaInterventional Radiology Department, Institut Paoli Calmettes, Aix Marseille University, 232 Boulevard Sainte Marguerite, 13009, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the oncological efficacy and complications of cryoablation (CA) in treating lung metastases from colorectal cancer (CRC) at the lung periphery. MATERIALS AND

methodsThe inclusion criteria for this bicenter retrospective study included patients with histologically confirmed CRC, with radiologically confirmed lung metastases at the periphery of the lung (distance of less than or equal to 2 cm from the costal, diaphragmatic, or cervical pleura) treated with CA between January 2017 and June 2022. Patients with intra-parenchymal metastases or metastases close to the mediastinal pleura and patients without follow-up were excluded.

resultsSeventy-three patients were included (median age: 69 years, range 47.0-83.0; 38 males, 52.0%) with 113 metastases and 89 procedures. Technical success was achieved in all procedures. During follow-up (median 22 months), on a per metastasis basis, local recurrence occurred for 8/113 (7%) of the metastases in 7 patients at a median time of 19 months; 7 had concomitant distant recurrence. Local progression-free survival rates were 95% at 1 year and 89% at 2, 3, and 4 years. Distant progression occurred in 41/73 (56.2%) patients, significantly associated with a history of liver metastasis and synchronous lung metastasis (p < 0.05). The median chemotherapy-free survival was 14 (IQR (5.0-21.5)) months. Complications were predominantly mild or moderate, with a low incidence of severe complications.

conclusionCA demonstrates high rate of local control and appears well-tolerated in the treatment of peripheral lung metastases from CRC. The procedure offers a viable therapeutic option, allowing patients a significant period without chemotherapy. KEY POINTS: Question Despite its advantages over surgery, data on cryoablation of metastases from colorectal cancer at the periphery of the lung are lacking. Findings Cryoablation enabled very good local control, with local progression-free survival rates of 95% at 1 year and 89% at 2, 3, and 4 years. Clinical relevance Cryoablation is an effective treatment for local tumor control of lung metastases from colorectal cancer at the periphery of the lung. The treatment is well tolerated and can provide patients with substantial relief from chemotherapy.

Indexed as

Colorectal NeoplasmsCryosurgeryLung NeoplasmsAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeColorectal neoplasmsCryotherapyLungNeoplasm metastasisPleura

Identifiers

PMID39572449

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