Evidence map›Paper›PMID 39572411›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Effectiveness of the exhalation delivery system with fluticasone for treating chronic rhinosinusitis with nasal polyposis: a systematic review and meta-analysis.

Yun Jin Kang, Gulnaz Stybayeva, Se Hwan Hwang

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yun Jin KangDepartment of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea.ORCID http://orcid.org/0000-0002-7677-4219
Gulnaz StybayevaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Se Hwan HwangDepartment of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 14647, Korea. yellobird@catholic.ac.kr.ORCID http://orcid.org/0000-0002-2838-7820

Funding

National Research Foundation of Korea 2022R1F1A1066232Soonchunhyang University Research Fund Soonchunhyang University Research Fund
6 · The paper itself

Abstract

purposeWe evaluated the effects of two doses (186 µg and 372 µg) of exhalation delivery system with fluticasone (EDS-FLU) on chronic rhinosinusitis (CRS) with nasal polyp as a novel sinonasal delivery system.

methodsWe analyzed 5 studies retrieved from PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases up to April 2024, focusing on subjective and objective scores, and adverse and beneficial effects (responder and complete responder rates, improvements in Patient Global Impression of Change [PGIC] scores, and surgical indication rates before and after EDS-FLU use.

resultsOver 3 months, EDS-FLU significantly reduced polyp (mean difference [MD] - 1.1605; 95% confidence interval [CI] [- 1.3277; -0.9934], I

conclusionBoth doses of EDS-FLU significantly improved subjective and objective outcomes of CRS patients with nasal polyps. However, epistaxis and nasal septal erosive or ulcerative lesions were also considered.

Indexed as

Drug Delivery SystemsFluticasoneNasal PolypsRhinitisSinusitisAdministration, IntranasalChronic DiseaseHumansRhinosinusitisTreatment OutcomeFluticasoneChronic rhinosinusitisExhalation delivery system with fluticasoneFluticasoneIntranasal corticosteroidNasal polyps

Identifiers

PMID39572411

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.