Trial reportThe European respiratory journal2025
Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea.
Trial report in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00051363 (APPLES), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
APPLES: Apnea Positive Pressure Long-Term Efficacy Study
Who cites it
5 citing papers in PubMed.
- Procedural learning worsens with OSA severity in older adults and is insensitive to short exposure supplemental oxygen therapy.Sleep medicine · 2025Trial
- Review
- Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Sleep as a window into brain health: clinical implications of sleeping brain wave-structure associations.Sleep · 2025Article
- Pathological respiratory chemoreflex activation predicts improvement of neurocognitive function in response to continuous positive airway pressure therapy.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundObstructive sleep apnoea (OSA) is associated with neurocognitive dysfunction. However, randomised trials evaluating the effects of continuous positive airway pressure (CPAP) on neurocognition in those without dementia do not show a benefit. We thus aimed to assess whether arousal threshold (ArTH) modifies the effect of CPAP on neurocognitive function.
methodsWe performed a secondary analysis of a randomised, sham-controlled trial (Apnea Positive Pressure Long-term Efficacy Study (APPLES); ClinicalTrials.gov: NCT00051363). ArTH was estimated from polysomnography using a translatable method. Neurocognitive outcomes included the Sustained Working Memory Test-Overall Mid-Day (SWMT-OMD) score (executive function, primary outcome), with the Pathfinder Number Test total time (attention) and Buschke Selective Reminding Test sum recall (learning and memory) as secondary outcomes. Generalised linear modelling assessed whether the effect of CPAP was modified by baseline ArTH (treatment×ArTH interaction). 833 participants with OSA (apnoea-hypopnoea index ≥10 events·h
resultsFor executive function, the effect of CPAP treatment was modified by ArTH (p
conclusionIn OSA, a higher ArTH is associated with greater improvements in executive function following CPAP therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.