ArticleChest2025
Dietary Pattern, Sputum DNA Methylation, and Lung Health: An Epidemiological Study in People Who Ever Smoked.
Article in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Triangulating associations between fruit intake and lung cancer risk: evidence from GBD estimates, Mendelian randomization, and real-world validation.The oncologist · 2026Article
- WCRF/AICR dietary adherence-associated metabolic bridge phenotypes and incident lung cancer risk: a prospective cohort study of the UK Biobank.Frontiers in nutrition · 2026Article
- Pulmonary Function and Influencing Factor Investigation for Rural Homemakers in the Fenwei Plain, China.Toxics · 2025Article
- Dietary Habits, Residential Air Pollution, and Chronic Obstructive Pulmonary Disease.Nutrients · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundWe previously identified a sputum 12-gene methylation panel that predicts lung aging and risk for lung cancer. RESEARCH QUESTION: Can the sputum methylation panel be used as a readout to derive a dietary pattern beneficial for lung health? Is this dietary pattern associated with various subjective and objective lung health phenotypes? Does this relationship vary among people who currently smoke vs previously smoked? STUDY DESIGN AND
methodsUsing the Lovelace Smoker Cohort (LSC), we employed the least absolute shrinkage and selection operator regularized Poisson regression to define a dietary pattern for sputum. Associations of the dietary pattern with objective and subjective lung health measurements were examined using generalized linear and Cox models in the LSC and the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening trial.
resultsThe Dietary Pattern for Healthy Lung (DiPHeaL) includes low consumption of processed meat, and high consumption of dark green vegetables, tea, alcohol, and fruit juice. In the LSC, a higher DiPHeaL score (1 SD) was associated with better FEV
interpretationWe defined a novel dietary pattern for lung epigenetic aging, which linked to lung health measurements. Participants who previously smoked, especially those with airway obstruction, may benefit the most from nutritional modification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.