Evidence map›Paper›PMID 39571575›Full record

ArticleImmunity2024

A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control.

Yutao Wang, Yanbo Zhang, Kyungsub Kim, Jichang Han, Daniel Okin, Zhaozhao Jiang, Liang Yang, Arum Subramaniam, Terry K Means, Frank O Nestlé and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Tracing LYVE1bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yutao WangDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Yanbo ZhangDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Kyungsub KimCenter for Bacterial Pathogenesis and Department of Microbiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jichang HanDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
Daniel OkinDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Zhaozhao JiangDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Liang YangDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Arum SubramaniamImmunology and Inflammatory Research Therapeutic Area, Sanofi, Cambridge, MA, USA.
Terry K MeansImmunology and Inflammatory Research Therapeutic Area, Sanofi, Cambridge, MA, USA.
Frank O NestléImmunology and Inflammatory Research Therapeutic Area, Sanofi, Cambridge, MA, USA.
Katherine A FitzgeraldDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Gwendalyn J RandolphDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
Cammie F LesserCenter for Bacterial Pathogenesis and Department of Microbiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jonathan C KaganDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address: cbdm@hms.harvard.edu.

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Research Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6M
DIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3M
Regulation of immunity by the cGAS-STING pathwayR01AI167993 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI JONATHAN C KAGAN · 2022 to 2026
$3.9M
Defining the pathways activated by Toll-like Receptors to stimulate immunityR37AI116550 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI JONATHAN C KAGAN · 2021 to 2026
$3.3M
Shigella mediated regulation of epithelial cell inflammasomesR01AI169795 · NIAID · TUFTS UNIVERSITY BOSTON · PI CAMMIE LESSER · 2023 to 2026
$3.0M
Treg cell diversity and homeostatic controlR01AI150686 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2020 to 2024
$2.6M
Characterization of the myddosome, a protein complex that controls TLR signalingR01AI116550 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KAGAN, JONATHAN C · 2017 to 2020
$1.8M
Deciphering the role of tumor-macrophage crosstalk during metastatic dissemination to the peritoneumK00CA264434 · NCI · WASHINGTON UNIVERSITY · PI HAN, JICHANG · 2022 to 2025
$388k
NCI NIH HHS K00 CA264434NHLBI NIH HHS T32 HL116275NIAID NIH HHS R01 AI116550NIAID NIH HHS R01 AI150686NIAID NIH HHS R01 AI167993NIAID NIH HHS R01 AI169795NIAID NIH HHS R37 AI049653NIAID NIH HHS R37 AI116550NIAID NIH HHS T32 AI007061NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

Ligand-dependent transcription factors of the nuclear receptor (NR) family regulate diverse aspects of metazoan biology, enabling communications between distant organs via small lipophilic molecules. Here, we examined the impact of each of 35 NRs on differentiation and homeostatic maintenance of all major immunological cell types in vivo through a "Rainbow-CRISPR" screen. Receptors for retinoic acid exerted the most frequent cell-specific roles. NR requirements varied for resident macrophages of different tissues. Deletion of either Rxra or Rarg reduced frequencies of GATA6

Indexed as

InflammasomesReceptors, Cytoplasmic and NuclearAnimalsCARD Signaling Adaptor ProteinsCell DifferentiationCRISPR-Cas SystemsGATA6 Transcription FactorLigandsMacrophages, PeritonealMiceMice, Inbred C57BLMice, KnockoutPyroptosisReceptors, Retinoic AcidRetinoic Acid Receptor gammaRetinoid X Receptor alphaCARD Signaling Adaptor ProteinsGATA6 Transcription FactorInflammasomesLigandsReceptors, Cytoplasmic and NuclearReceptors, Retinoic AcidRetinoic Acid Receptor gammaRetinoid X Receptor alpha

Identifiers

PMID39571575
PMCPMC11634661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.