ArticleGynecologic and obstetric investigation2025
Global, Regional, and National Prevalence and Disability-Adjusted Life-Years for Female Infertility: Results from a Global Burden of Disease Study, 1990-2019.
Article in Gynecologic and obstetric investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Synergistic Amelioration of Imidacloprid-Induced fertility impairment by Vitex agnus-castus and Nigella sativa in Female Rats: Mechanistic Evidence of Hormonal and Reproductive Restoration.Cell biochemistry and biophysics · 2026Article
- Beyond euploidy: the synergistic value of blastocyst morphology in predicting ongoing implantation in advanced maternal age women.Reproduction & fertility · 2026Article
- Boosting psychological well-being in infertile women undergoing IVF through Fordyce happiness counseling: a quasi-experimental approach in Zahedan, Southeast Iran.Preventive medicine reports · 2026Article
- Epidemiological characteristics of infertility, 1990-2021, and 15-year forecasts: an analysis based on the global burden of disease study 2021.Reproductive health · 2025Article
- Observational
- Adherence to a healthy lifestyle in association with female infertility risk: the mediating role of uric acid.Frontiers in nutrition · 2025Article
- Rising global burden of migraine among adolescents and young adults: a 30-year analysis (1990-2021).Frontiers in neurology · 2025Article
- Using Life's Essential 8 and heavy metal exposure to determine infertility risk in American women: a machine learning prediction model based on the SHAP method.Frontiers in endocrinology · 2025Article
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4 authors.
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Abstract
objectivesWe aimed to determine the prevalence of female infertility in 204 countries and territories from 1990 to 2019.
designWe evaluated the female infertility global burden between 1990 and 2019 in this systematic study. MATERIALS: The Global Health Data Exchange query tool (http://ghdx.healthdata.org/gbd-results-tool) and sociodemographic index (SDI) (http://ghdx.healthdata.org/data-type/estimate) provided data on the annual prevalence numbers, age-standardized prevalence rates (ASR), and disability-adjusted life-years (DALYs) of female infertility in 204 countries and territories from 1990 to 2019 for various age groups.
settingFemale infertility has a devastating impact on the physical and mental health of individuals and national fertility. However, most of the previous studies on this subject were conducted on rather small sample sizes and have certain limitations.
methodsWe examined female infertility in terms of prevalence, ASR, and DALYs across different age groups in 204 countries and territories from 1990 to 2019 using data from the Global Health Data Exchange query tool.
resultsFrom 1990 to 2019, ASR and DALYs for female infertility increased globally. At the SDI quintile level, middle-SDI and high-middle-SDI countries exhibited a faster increase in the ASR of female infertility. In 2019, with the highest female infertility rate recorded among those between the ages of 30-34 years and the lowest among those between the ages of 45-49 years. In 2019, high-income North America recorded the highest proportion of primary infertility, while East Asia recorded the lowest proportion. LIMITATIONS: First, the global burden of disease (GBD) database lacks data for some countries and regions. Second, data access and quality differ across locations. Third, the causes of infertility are not comprehensive, and data on Klinefelter in GBD 2019 in relation to primary infertility were absent.
conclusionGlobally, the prevalence of DALYs and age-standardized female infertility rates increased from 1990 to 2019.
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