Evidence map›Paper›PMID 39571410›Full record

ArticleNeurobiology of aging2025

Cross-sectional and longitudinal relationships among blood-brain barrier disruption, Alzheimer's disease biomarkers, and cognition in cognitively normal older adults.

Marisa Denkinger, Suzanne Baker, Theresa M Harrison, Trevor Chadwick, William J Jagust

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marisa DenkingerDepartment of Neuroscience, University of California, Berkeley, CA, United States. Electronic address: marisa_becerra@berkeley.edu.
Suzanne BakerLawrence Berkeley National Laboratory, Berkeley, CA, United States.
Theresa M HarrisonDepartment of Neuroscience, University of California, Berkeley, CA, United States.
Trevor ChadwickDepartment of Neuroscience, University of California, Berkeley, CA, United States.
William J JagustDepartment of Neuroscience, University of California, Berkeley, CA, United States; Lawrence Berkeley National Laboratory, Berkeley, CA, United States. Electronic address: jagust@berkeley.edu.

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
The blood-brain barrier and Alzheimer pathologyR01AG080043 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI William J. Jagust, Daniela KAUFER · 2023 to 2026
$2.7M
Linking basal forebrain and entorhinal cortex vulnerability to preclinical Alzheimer's diseaseK01AG078443 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Theresa M. Harrison · 2022 to 2026
$656k
Relationships between blood-brain barrier breakdown, Alzheimer's disease pathology, and memory in agingF31AG072872 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DENKINGER, MARISA NICOLE · 2022 to 2023
$79k
NIA NIH HHS F31 AG072872NIA NIH HHS K01 AG078443NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG080043
6 · The paper itself

Abstract

Blood-brain barrier disruption (BBBd) occurs in aging, particularly in regions vulnerable to Alzheimer's disease (AD) pathology. However, its relationship to pathological protein accumulation, neurodegeneration, and cognitive impairment in normal aging is unclear. We used dynamic contrast-enhanced MRI (DCE-MRI) and positron emission tomography (PET) imaging in cognitively normal older adults to explore how BBBd correlates with brain atrophy and cognitive function, and whether these relationships are influenced by Aβ or tau. We found that greater BBBd in the hippocampus (HC) and an averaged BBBd-susceptible ROI were linked to worse episodic memory, with interactions between BBBd and atrophy influencing this relationship, independent of Aβ and tau. However, there were no significant relationships between BBBd and non-memory cognitive performance. In participants with longitudinal AD biomarker and cognitive data acquired prior to DCE-MRI, faster longitudinal entorhinal cortex (EC) tau accumulation and episodic memory decline were associated with greater HC BBBd, independent of global Aβ changes and regional atrophy. These findings enhance our understanding of the complex relationships between AD biomarkers, cognitive decline, and BBBd.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAtrophyBiomarkersBlood-Brain BarrierCognitionMagnetic Resonance ImagingMemory, EpisodicPositron-Emission Tomographytau ProteinsAgedAged, 80 and overAgingCognitive DysfunctionCross-Sectional StudiesFemaleAmyloid beta-PeptidesBiomarkerstau ProteinsAgingAmyloidAtrophyBlood-brain barrier disruptionEpisodic memoryTau

Identifiers

PMID39571410
PMCPMC13333117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.