Evidence map›Paper›PMID 39571137›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2025

Microstructural Damage and Repair in the Spinal Cord of Patients With Early Multiple Sclerosis and Association With Disability at 5 Years.

Malo Gaubert, Benoit Combès, Elise Bannier, Arthur Masson, Vivien Caron, Gaëlle Baudron, Jean-Christophe Ferré, Laure Michel, Emmanuelle Le Page, Bruno Stankoff and 3 more

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Article in Neurology(R) neuroimmunology & neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Malo GaubertFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0000-0003-0452-8905
Benoit CombèsFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.
Elise BannierFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0000-0002-8942-7486
Arthur MassonFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.
Vivien CaronFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0009-0003-5347-4592
Gaëlle BaudronFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.
Jean-Christophe FerréFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0000-0003-3911-1800
Laure MichelFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0000-0002-8119-7794
Emmanuelle Le PageFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0000-0002-7849-2266
Bruno StankoffFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0000-0002-9631-4674
Gilles EdanFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0000-0002-9641-6734
Benedetta BodiniFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.
Anne KerbratFrom the Department of Neuroradiology (M.G., E.B., J.-C.F.), Rennes University Hospital; Empenn (M.G., B.C., E.B., A.M., V.C., G.B., J.-C.F., A.K.), INRIA, Rennes University-CNRS-INSERM; Department of Neurology (L.M., E.L.P., G.E., A.K.), Rennes University Hospital; Paris Brain Institute (ICM) (B.S., B.B.), Sorbonne University-CNRS-INSERM; and Neurology Department (B.S., B.B.), APHP St Antoine Hospital, Paris, France.ORCID 0000-0002-4530-3553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe dynamics of microstructural spinal cord (SC) damage and repair in people with multiple sclerosis (pwMS) and their clinical relevance have yet to be explored. We set out to describe patient-specific profiles of microstructural SC damage and change during the first year after MS diagnosis and to investigate their associations with disability and SC atrophy at 5 years.

methodsWe performed a longitudinal monocentric cohort study among patients with relapsing-remitting MS: first relapse <1 year, no relapse <1 month, and high initial severity on MRI (>9 T2 lesions on brain MRI and/or initial myelitis). pwMS and age-matched healthy controls (HCs) underwent cervical SC magnetization transfer (MT) imaging at baseline and at 1 year for pwMS. Based on HC data, SC MT ratio

resultsThirty-seven patients and 19 HCs were included. We observed considerable variability in the extent of microstructural SC damage at baseline (0%-58% of SC voxels). We also observed considerable variability in damage and repair indices over 1 year (0%-31% and 0%-20%), with 18 patients showing predominance of damage and 18 predominance of repair. The index of microstructural damage was associated positively with the Expanded Disability Status Scale score ( DISCUSSION: People with early relapsing-remitting MS exhibited heterogeneous profiles of microstructural SC damage and repair. Progression of microstructural damage was associated with disability progression and SC atrophy 5 years later. These results indicate a potential for microstructural repair in the SC to prevent disability progression in pwMS.

Indexed as

Magnetic Resonance ImagingMultiple Sclerosis, Relapsing-RemittingSpinal CordAdultAtrophyDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle Aged

Identifiers

PMID39571137
PMCPMC11587990

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