Observational studyNeurology2024
Primary Progressive Aphasia in Italian and English: A Cross-Linguistic Cohort Study.
Abstract readObservational StudyComparative Study
In one paragraph
Observational study in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Speech-In-Noise Perception in Alzheimer's Disease and Primary Progressive Aphasia.European journal of neurology · 2026Article
- Rethinking Alzheimer's disease susceptibility and heterogeneity. Comment on Miller et al.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Staging Language-Led Neurodegenerative Diseases in a Language-Based World: The Challenge of the PPA-Squared Scale.European journal of neurology · 2026Article
- Two Languages and One Aphasia: A Systematic Scoping Review of Primary Progressive Aphasia in Chinese Bilingual Speakers, and Implications for Diagnosis and Clinical Care.Brain sciences · 2025Review
- Applicability and Correlates of a Symptom-Led Staging System for Primary Progressive Aphasia.European journal of neurology · 2025Article
- Language disorders in understudied languages: Opening editorial.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Digital phenotyping of Parkinson's disease via natural language processing.NPJ Parkinson's disease · 2025Article
- Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions.Frontiers in aging neuroscience · 2025Article
- Redefining the norms: an interdisciplinary perspective on language testing in multilinguals with acquired and progressive neurogenic disorders.Alzheimer's & dementia (Amsterdam, Netherlands)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Salvatore MazzeoFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0001-5985-5060
Chris J D HardyFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0002-4900-6492
Jessica JiangFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Carmen MorinelliFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Valentina MoschiniFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Ella BrooksFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Jeremy C S JohnsonFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Anthipa ChokesuwattanaskulFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0001-7973-8267
Giulia GiacomucciFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0002-8711-331X
Anna VolkmerFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0002-4149-409X
Jonathan D RohrerFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0002-6155-8417
Assunta IngannatoFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Silvia BagnoliFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Sonia PadiglioniFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Benedetta NacmiasFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0001-9338-9040
Sandro SorbiFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0002-0380-6670
Valentina BessiFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.ORCID 0000-0002-6176-3584
Jason D WarrenFrom the Dementia Research Centre (S.M., C.J.D.H., J.J., E.B., J.C.S.J., A.C., J.D.R., J.D.W.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom; Research and Innovation Centre for Dementia-CRIDEM (S.M., C.M., V.M., S.P., S.S., V.B.), Azienda Ospedaliero-Universitaria Careggi, Florence; Vita-Salute San Raffaele University (S.M.), Milan; IRCCS Policlinico San Donato (S.M.), San Donato Milanese, Italy; Division of Neurology (A.C.), Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society; Cognitive Clinical and Computational Neuroscience Research Unit (A.C.), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; University of Florence (G.G.), Italy; Department of Psychology & Language Sciences (A.V.), University College London, United Kingdom; Department of Neuroscience, Psychology, Drug Research and Child Health (A.I., S.B., B.N., S.S.), University of Florence, Azienda Ospedaliera-Universitaria Careggi; and IRCCS Fondazione Don Carlo Gnocchi (B.N., S.S., V.B.), Florence, Italy.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesCurrent formulations of primary progressive aphasia (PPA) derive largely from English-speaking patients. We hypothesized that language-specific characteristics influence PPA phenotypes in 2 contrasting languages: Italian and English.
methodsWe undertook a retrospective, cross-sectional, observational comparison of 2 patient cohorts representing all major PPA syndromes, in London and Florence. Neuropsychological scores in a range of linguistic and general cognitive domains were normalized to native speaker controls and dichotomized as impaired/unimpaired. Proportions were compared using χ
resultsThe cohorts comprised 106 (48.1% female) Italian speakers (14 nonfluent/agrammatic [nfvPPA], 20 semantic [svPPA], 41 logopenic variant [lvPPA], 31 mixed PPA [mPPA]) and 166 (45.2% female) English speakers (70 nfvPPA, 45 svPPA, 42 lvPPA, 9 mPPA). Comparing cohorts, the English cohort was younger (mean 62.7 [SD = 8.4] vs 65.9 [7.8] years; DISCUSSION: Language-specific characteristics influenced PPA phenotypes, with more frequent expressive agrammatism in Italian (reflecting its morphologic complexity), more frequently impaired word processing in English (reflecting its articulatory, acoustic, and orthographic complexity), and increased prevalence of mPPA in Italian. These findings have implications for PPA diagnosis and management. Limitations of test heterogeneity and cohort size should be addressed in future, prospective, multicenter initiatives using cross-linguistic tools.
Indexed as
Aphasia, Primary ProgressiveLanguageAgedCohort StudiesCross-Sectional StudiesFemaleHumansItalyMaleMiddle AgedNeuropsychological TestsRetrospective Studies
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