ArticleScience (New York, N.Y.)2024
Hidden state inference requires abstract contextual representations in the ventral hippocampus.
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Computational origins of cortical brain circuits for social cognition.Nature reviews. Neuroscience · 2026Review
- A mathematical theory for understanding when abstract representations emerge in neural networks.ArXiv · 2026Article
- Building Goal-Directed Cognitive Graphs.bioRxiv : the preprint server for biology · 2026Article
- Contextual inference through flexible integration of environmental features and behavioural outcomes.PLoS computational biology · 2026Article
- Layers of Social Meaning: Innate, Acquired, and Deliberative Levels of Referential Signal Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques.Nature communications · 2026Article
- Complementary roles of dorsal and ventral hippocampus in the flexible adaptation of goal-directed behavior.Science advances · 2025Article
- Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- A common computational and neural anomaly across mouse models of autism.Nature neuroscience · 2025Article
- Nucleus accumbens dopamine release reflects Bayesian inference during instrumental learning.PLoS computational biology · 2025Article
- Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors.bioRxiv : the preprint server for biology · 2025Article
- Hidden state inference requires abstract contextual representations in the ventral hippocampus.Science (New York, N.Y.) · 2024Article
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Authors and funding
7 authors.
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Abstract
The ability to use subjective, latent contextual representations to influence decision-making is crucial for everyday life. The hippocampus is hypothesized to bind together otherwise abstract combinations of stimuli to represent such latent contexts, to support the process of hidden state inference. Yet evidence for a role of the hippocampus in hidden state inference remains limited. We found that the ventral hippocampus is required for mice to perform hidden state inference during a two-armed bandit task. Hippocampal neurons differentiate the two abstract contexts required for this strategy in a manner similar to the differentiation of spatial locations, and their activity is essential for appropriate dopamine dynamics. These findings offer insight into how latent contextual information is used to optimize decisions, and they emphasize a key role for the hippocampus in hidden state inference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.