ArticleSleep2025
The association between hypoxic burden and the risk of cognitive impairment in patients with obstructive sleep apnea.
Article in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The hypoxic burden algorithm: an integrated index for assessing intermittent hypoxia in pediatric obstructive sleep apnea-a retrospective cohort study.Translational pediatrics · 2026Article
- Article
- Hypoglossal Nerve Stimulation and Hypoxic Burden in Patients With Obstructive Sleep Apnea: A Secondary Analysis of the STAR Trial.JAMA otolaryngology-- head & neck surgery · 2026Article
- Review
- A Global Burden Perspective on Obstructive Sleep Apnea, Hearing Loss, and Early-Onset Cognitive Decline.Neurology international · 2026Review
- Sleep spindle density increases in patients with severe obstructive sleep apnea after 6 months of treatment: a longitudinal study.Scientific reports · 2026Article
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Vitamin D and Mean Platelet Volume as Biomarkers in Pediatric Obstructive Sleep Apnea: Associations with Disease Severity and Sleep Parameters.Journal of clinical medicine · 2026Article
- Telomere dysfunction is associated with exacerbated intermittent hypoxia-induced cognitive deficits and nerve damage.Frontiers in aging neuroscience · 2026Article
- Development and internal validation of a LASSO-based nomogram for predicting SAS-defined anxiety symptoms in obstructive sleep apnea.Frontiers in psychiatry · 2026Article
- Multi-dimensional sleep patterns predict complications and mortality in chronic kidney disease patients: a prospective study from the UK Biobank.Frontiers in public health · 2026Article
- Article
- Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank.BMC medicine · 2025Article
- Beyond traditional hypoxemia metrics: hypoxic burden as a predictor of cognitive dysfunction in sleep apnea.Sleep · 2025Article
- Gait Characteristics and Neuroanatomical Alterations in Obstructive Sleep Apnea-Hypopnea Syndrome.Nature and science of sleep · 2025Article
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7 authors.
Funding
Abstract
STUDY
objectivesObstructive sleep apnea (OSA) is associated with an increasing risk of cognitive impairment, but traditional hypoxic indicators can not accurately identify cognitive impairment. This study aimed to assess a new indicator, hypoxic burden, in cognitive impairment in OSA.
methodsA total of 116 patients with OSA were enrolled in this study. Daytime sleepiness and cognition were assessed using the Epworth Sleepiness Scales and Montreal Cognitive Assessment (MoCA), respectively. All participants underwent polysomnography (PSG). The hypoxic burden was derived from PSG and calculated according to a specific algorithm. All the participants were divided into two groups. Seventy-seven were OSA with mild cognitive impairment (OSA + MCI), and 39 were OSA without mild cognitive impairment (OSA-MCI). The relationship between hypoxic burden and cognitive impairment was analyzed by establishing a series of logistic regression models.
resultsHypoxic burden was higher in OSA + MCI group compared with OSA-MCI group, while there was no significance found for the apnea-hypopnea index between the two groups. After adjusting for various confounders, patients with OSA who had a higher total hypoxic burden and rapid eye movement-hypoxic burden in the fourth quartile were found to have an increased risk of MCI compared to those in the first quartile. The adjusted ORs were 7.69 (95% CI, 1.15 to 51.55) and 8.87 (95% CI, 1.22 to 64.34), respectively. However, There was no significant association between the other traditional hypoxic parameters and cognitive function after adjusting for various confounders.
conclusionsCompared to the conventional hypoxic parameter, a higher hypoxic burden is associated with cognition and may be an important indicator for assessing MCI in OSA.
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