Evidence map›Paper›PMID 39570753›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Unveiling the Mechanism of Deprotonation and Proton Transfer of DNA Polymerase Catalysis via Single-Molecule Conductance.

Lihua Zhao, Yang Xu, Zhiheng Yang, Wenzhe Liu, Shichao Zhong, Jingwei Bai, Xuefeng Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lihua ZhaoBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, 292 Chengfu Road, Haidian District, Beijing, 100871, P. R. China.
Yang XuSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, 100093, P. R. China.
Zhiheng YangBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, 292 Chengfu Road, Haidian District, Beijing, 100871, P. R. China.
Wenzhe LiuBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, 292 Chengfu Road, Haidian District, Beijing, 100871, P. R. China.
Shichao ZhongBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, 292 Chengfu Road, Haidian District, Beijing, 100871, P. R. China.
Jingwei BaiSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, 100093, P. R. China.ORCID 0000-0002-2630-2395
Xuefeng GuoBeijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, 292 Chengfu Road, Haidian District, Beijing, 100871, P. R. China.ORCID 0000-0001-5723-8528

Funding

Beijing National Laboratory for Molecular Sciences BNLMS-CXXM-202407"Frontiers Science Center for New Organic Matter" at Nankai University 63181206National Key R&D Program of China 2021YFA1200101National Key R&D Program of China 2022YFE0128700National Natural Science Foundation of China 21933001National Natural Science Foundation of China 22150013Natural Science Foundation of Beijing 2222009
6 · The paper itself

Abstract

DNA polymerases (Pols) play important roles in the transmission of genetic information. Although the function and (de)regulation of Pols are linked to many human diseases, the key mechanism of 3'-OH deprotonation and the PP

Indexed as

DNA-Directed DNA PolymeraseCatalysisGraphiteHumansProtonsDNA-Directed DNA PolymeraseGraphiteProtonscatalysis mechanismDNA polymeraseelectric fieldGMG biosensorhPol β proteinsingle‐molecule level

Identifiers

PMID39570753
PMCPMC11727276

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.