Evidence map›Paper›PMID 39570553›Full record

ReviewDiscover oncology2024

Anticancer effect of Moringa oleifera in oral squamous cell carcinoma: a systematic review.

Chandini Rajkumar, Saranya Ramsridhar, Vishnu Priya Veeraraghavan, Arul Prakash Francis, M Purushotham, Uma Mageshwari

Abstract readReview
In one paragraph

Review in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Harnessing the anticancer potential ofAnnals of medicine and surgery (2012) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chandini RajkumarSaveetha Institute of Medical and Technical Sciences, Chennai, India. chandinirajkumar@gmail.com.
Saranya RamsridharSathyabama Institute of Science and Technology, Chennai, India.
Vishnu Priya VeeraraghavanSaveetha Institute of Medical and Technical Sciences, Chennai, India.
Arul Prakash FrancisSaveetha Institute of Medical and Technical Sciences, Chennai, India.
M PurushothamPriyadarshini Dental College and Hospital, Chennai, India.
Uma MageshwariSathyabama Institute of Science and Technology, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveOral squamous cell carcinoma is the most common form of mouth cancer. As plant-based medicines become increasingly popular, Moringa oleifera has been studied extensively for its plant-based components, and health benefits. The present review examined the anticancer effects of Moringa oleifera extracts on Oral squamous cell carcinoma. MATERIALS AND

methodsThe study complied with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards. A comprehensive search was performed on PubMed, Scopus, and Google Scholar to find research papers published from January 2015 to August 2024 that assessed the effects of extracts of various parts of Moringa oleifera in Oral squamous cell carcinoma. Two independent reviewers separately assessed research study titles, abstracts, and the chosen full-text papers. The risk of bias in non-randomized exposure studies was classified as low, with some concerns high and extremely high.

resultsThe final review yielded four in-vitro investigations, two molecular analyses, and five animal models. The study revealed that Moringa oleifera plant components have antioxidant, anti-inflammatory, anticancer, and chemo-preventive properties. All the 11 studies showed a low risk of bias.

conclusionThe studies reviewed herein reveal that Moringa oleifera plant components have antioxidant, anti-inflammatory, anticancer, and chemopreventive properties. Although more clinical trials are needed to fully establish its efficacy and safety as a complementary therapy, the growing body of evidence positions Moringa oleifera as a promising natural adjunct to cancer treatment strategies.

Indexed as

Anti-proliferative activityLeaf extractMoringa oleifera Lam.Oral squamous cell carcinomaSCC15 cell lines

Identifiers

PMID39570553
PMCPMC11582275

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.