Evidence map›Paper›PMID 39570548›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Neuromuscular Organoids to Study Spinal Cord Development and Disease.

Tobias Grass, Zeynep Dokuzluoglu, Natalia Rodríguez-Muela

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tobias GrassGerman Center for Neurodegenerative Diseases e.V. (DZNE), Dresden, Germany.
Zeynep DokuzluogluGerman Center for Neurodegenerative Diseases e.V. (DZNE), Dresden, Germany.
Natalia Rodríguez-MuelaGerman Center for Neurodegenerative Diseases e.V. (DZNE), Dresden, Germany. natalia.rodriguez-muela@dzne.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many aspects of neurodegenerative disease pathology remain unresolved. Why do certain neuronal subpopulations acquire vulnerability to stress or mutations in ubiquitously expressed genes, while others remain resilient? Do these neurons harbor intrinsic marks that make them prone to degeneration? Do these diseases have a neurodevelopmental component? Lacking this fundamental knowledge hampers the discovery of efficacious treatments. While it is well established that human organoids enable the modeling of brain-related diseases, we still lack an organoid model that recapitulates the regionalization complexity and physiology of the spinal cord. Here, we describe an advanced experimental protocol to generate neuromuscular organoids composed of a wide rostro-caudal (RC) diversity of spinal motor neurons (spMNs) and mesodermal progenitor-derived muscle cells. This model therefore allows for the robust and reproducible study of neuromuscular unit development and disease.

Indexed as

Neuromuscular JunctionOrganoidsSpinal CordAnimalsHumansMiceMotor NeuronsHuman induced pluripotent stem cellsNeuromesodermal progenitorsNeuromuscular spinal cord organoidsSkeletal and smooth muscleSpinal motor neurons

Identifiers

PMID39570548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.