Evidence map›Paper›PMID 39570518›Full record

ArticleDermatology and therapy2024

The Atopic Dermatitis Control Tool: Adaptation and Content Validation for Children and Caregivers of Children with Atopic Dermatitis.

Chien-Chia Chuang, David M Pariser, Eric Simpson, Jennifer Dine, Michelle Brown, Sheri Fehnel, Zhixiao Wang

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Article in Dermatology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Chien-Chia ChuangSanofi, Cambridge, MA, USA. Chien-chia.Chuang@sanofi.com.
David M PariserEastern Virginia Medical School and Virginia Clinical Research Inc, Norfolk, VA, USA.
Eric SimpsonOregon Health and Science University, Portland, OR, USA.
Jennifer DineResearch Triangle Institute Health Solutions, Research Triangle Park, Raleigh, NC, USA.
Michelle BrownResearch Triangle Institute Health Solutions, Research Triangle Park, Raleigh, NC, USA.
Sheri FehnelResearch Triangle Institute Health Solutions, Research Triangle Park, Raleigh, NC, USA.
Zhixiao WangRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Atopic Dermatitis Control Tool (ADCT) assesses six concepts regarding patient-perceived control of atopic dermatitis (AD) in adults and adolescents with AD. This study aimed to develop two modified ADCT versions, one for children with AD aged 8-11 years and another for caregivers of children with AD aged 6 months to 11 years.

methodsFollowing the US Food and Drug Administration patient-reported outcomes guidance, the ADCT was modified to produce draft Child and Caregiver ADCT versions, maintaining the original six concepts. The instruments were refined and finalized through an iterative process using input from children with AD and caregivers of children with AD via qualitative interviews. Inclusion criteria were clinician diagnosis of AD, prescription treatment use in the past 3 months, and itching/scratching or rash in the past month. Interviews consisted of concept elicitation to identify perceptions of AD control and cognitive debriefing to test and refine the ADCT items.

resultsIn total, 19 children (mean age 9.2 years, 74% male) and 17 caregivers (mean age 36.3 years, 100% female) were interviewed. During concept elicitation, children and caregivers reported similar symptoms and described the cycling and unpredictability of AD. Most participants reported that daily activities were impacted negatively by AD symptoms. The concept of AD control resonated with children and caregivers, and respondents were able to describe their experiences related to AD symptom severity. Children were unfamiliar with the term AD, so the Child ADCT version was named the Child Eczema Control Tool (ECT). Children and caregivers both reported that the instruments assessed relevant concepts, comprehensively measured AD control, and demonstrated content and face validity.

conclusionsThe Child ECT and Caregiver ADCT were developed and qualitatively validated for assessing AD control in patients aged 6 months to 11 years and may offer simple ways to assess disease control and optimize treatment decisions. Video Abstract.

Indexed as

ADCTAtopic dermatitisDisease controlPatient-reported outcomesPediatric AD patients

Identifiers

PMID39570518
PMCPMC11604878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.