ArticleAnnals of biomedical engineering2025
A Comparative Analysis of Alpha and Beta Therapy in Prostate Cancer Using a 3D Image-Based Spatiotemporal Model.
Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A mechanical reprogramming: synergistic tumor microenvironment normalization improves nano-immunotherapy delivery in prostate cancer via multiphysics modeling.Drug delivery and translational research · 2026Article
- Recent Advances in Radiopharmaceuticals for Cancer Diagnosis and Therapy.Oncology research · 2026Review
- The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy.Military Medical Research · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
purposeIn treating prostate cancer, distinguishing alpha and beta therapies is vital for efficient radiopharmaceutical delivery. Our study introduces a 3D image-based spatiotemporal computational model that utilizes MRI-derived images to evaluate the efficacy of
methodsAn MRI-based geometric model of the tumor and its surrounding environment is initially developed. Subsequently, COMSOL Multiphysics software is utilized to solve convection-diffusion-reaction equations and conduct numerical analyses of blood pressure distribution. This computational methodology provides valuable insights into interstitial fluid patterns and the spatiotemporal distribution of extracellular and intracellular concentrations of
resultsLarger tumors have diminished absorbed doses, highlighting the need for customized treatments according to tumor size. Diffusion significantly influences the transport and delivery of radiopharmaceuticals. Additionally, alpha therapy was observed to consistently yield higher absorbed doses within the tumor than beta therapy.
conclusionsThis study reveals the complex interplay between radiopharmaceutical properties, the tumor microenvironment, and treatment outcomes. It highlights the potential of
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