Evidence map›Paper›PMID 39570453›Full record

ArticleParasitology research2024

IL-33 deficiency inhibits Toxoplasma gondii infection by promoting NLRP3 inflammasome.

Yizhong Chen, Xiaoli He, Yuqin Chen, Rongzhao Zhang, Tengwen Zhang, Tao Zhang, Linqing Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yizhong Chen *The Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Xiaoli He *The Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Yuqin ChenThe Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Rongzhao ZhangThe Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Tengwen ZhangThe Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Tao ZhangThe Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. zjdrzht@fjmu.edu.cn.
Linqing WuThe Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. wu_linqing@hotmail.com.

Funding

Natural Science Foundation of Fujian 2019J01679
6 · The paper itself

Abstract

NLRP3 inflammasome-mediated inflammatory responses play pivotal functions in innate immunity. However, its homeostatic regulation still needs to be better understood. Here we explore the effect and potential mechanism of IL-33 on NLRP3 inflammasome upon Toxoplasma gondii infection through a series of molecular biology and immunological experiments, including western blot, qRT-PCR, and ELISA. We demonstrated that T. gondii infection induces the expression of IL-33, and IL-33-deficient (IL-33

Indexed as

InflammasomesInterleukin-33Mice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinToxoplasmaAnimalsMacrophagesMiceMice, Inbred C57BLToxoplasmosisIl33 protein, mouseInflammasomesInterleukin-33NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseIL-33InflammationInnate immunityMacrophagesNLRP3 inflammasomePolarizationToxoplasma gondii

Identifiers

PMID39570453

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.