ArticleNaunyn-Schmiedeberg's archives of pharmacology2025
Global trends and biological activity hotspots of D-limonene in essential oils: a 30-year bibliometric study.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This study aims to conduct a comprehensive bibliometric analysis of global research trends and hotspots related to the biological activities of D-limonene, a prominent monoterpene compound found in essential oils, that warrant attention. We performed a bibliometric analysis of 1928 publications sourced from the Web of Science core database, covering the period from 1994 to 2024. Utilizing CiteSpace and VOSviewer software, we analyzed publication trends, collaboration networks among countries, institutions, and authors, and explored the evolution of research themes and current hotspots through keyword analysis. Our findings indicate a rapid increase in research on D-limonene activities since 2017, with China and Brazil leading in publication output. Italy and the USA play central roles within the collaboration network. Notably, a core group of authors has yet to emerge in this field. The biological activities of D-limonene, particularly its antibacterial, antioxidant, anti-inflammatory, and antitumor properties, are widely studied. Recent research hotspots focus on its neuroprotective effects and its potential role in inhibiting antibiotic resistance. The study highlights the growing interest in D-limonene and suggests that its use as an adjuvant to enhance therapeutic efficacy through synergistic interactions with other drugs may represent a significant research direction for the future. This analysis provides valuable insights for researchers and practitioners in pharmacology and related fields, emphasizing the importance of D-limonene in advancing health-related applications.
Indexed as
Identifiers
39570383What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.