Evidence map›Paper›PMID 39570380›Full record

ArticleWorld journal of urology2024

Risk factors for kidney cancer and socio-occupational category: significant impact of chlorinated solvents (UroCCR 111).

Matthieu Ferragu, Jean-Christophe Bernhard, Alexis Fontenil, Julien Guillotreau, Frédéric Panthier, Nicolas Branger, Olivier Belas, Jean-Jacques Patard, François Audenet, Louis Surlemont and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
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Article in World journal of urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Matthieu FerraguDepartment of Urology, Angers University Hospital, Angers, France. matthieu.Ferragu@chu-angers.fr.
Jean-Christophe BernhardDepartment of Urology, Bordeaux University Hospital, Bordeaux, France.
Alexis FontenilDepartment of Urology, Nîmes University Hospital, Nîmes, France.
Julien GuillotreauDepartment of Urology - Pasteur Clinic Toulouse, Toulouse, France.
Frédéric PanthierDepartment of Urology, Tenon Hospital, Paris, France.
Nicolas BrangerDepartment of Urology - Paoli Calmettes Institute, Marseille, France.
Olivier BelasPôle Santé Sud - Private Clinic, Le Mans, France.
Jean-Jacques PatardDepartment of Urology, Mont-de-Marsan Hospital, Mont-de-Marsan, France.
François AudenetDepartment of Urology, Hôpital Européen Georges Pompidou, Paris, France.
Louis SurlemontDepartment of Urology, Rouen University Hospital, Rouen, France.
Richard MalletDepartment of Urology, Francheville Polyclinic, Francheville, France.
Thibaut WaeckelDepartment of Urology, Caen Normandy University Hospital, Caen, France.
Pierre BigotDepartment of Urology, Angers University Hospital, Angers, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe rising incidence of renal cell carcinoma (RCC) is a significant concern in cancer research. This study analyses the characteristics of RCC patients based on their socio-professional category and explores the role of chlorinated solvents as a risk factor. MATERIALS AND

methodsA multicentre, descriptive epidemiological study was conducted using the UroCCR database. All patients from participating centres who had been diagnosed with RCC between July 2021 and February 2023, as well as those seen for follow-up consultation during this period, were included. Patients were categorised into 5 socio-professional groups based on INSEE's Profession and Social Categories classification. The characteristics and risk factors of RCC for each group were compared. Binary logistic regression was used to study the exposure to chlorinated solvents and risk factors for clear cell RCC (ccRCC).

resultsA total of 1252 patients were included. Males made up 69.6% of the population. The median age was 64 years, and 87% of the patients had at least one RCC risk factor. ccRCC, papillary, and chromophobe types accounted for 78%, 14.9%, and 8.5% of the population, respectively. The median tumor size was 4.5 cm (SD = 3.3). Farmers had a higher prevalence of ccRCC (91.3%; p = 0.05) and larger tumors (median = 6 cm SD = 3.23; p = 0.038) than patients from other populations. Smoking and obesity rates were lower (10.1%; p < 0.001; 15.9%, p = 0.018, respectively), but exposure to chlorinated solvents was higher (50.7%; p < 0.001). Exposure to chlorinated solvents was independently associated with higher TNM stages (p = 0.044, OR = 1.41 CI (1.01; 1.96)). Obesity and exposure to chlorinated solvents were independent risk factors for ccRCC (p = 0.006, OR = 1.6 CI (1.1;2.2) and p = 0.028, OR = 1.6 CI (1.1;2.6), respectively).

conclusionThis study shows the influence of socio-professional categories on exposure to RCC risk factors and tumor characteristics. In particular, farmers stood out from the rest of the study population. Their significant exposure to chlorinated solvents could be an interesting factor to investigate.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsOccupational ExposureSolventsAdultAgedFemaleHumansHydrocarbons, ChlorinatedMaleMiddle AgedRisk FactorsHydrocarbons, ChlorinatedSolventsChlorinated solventsEpidemiologyKidney cancerRisk factorsSocio-occupational category

Identifiers

PMID39570380
PMCPMC11582165

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.