ArticleEuropean journal of applied physiology2025
The reliability of functional and systemic markers of muscle damage in response to a flywheel squat protocol.
Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Context-Dependent Differences in Muscle Architecture Following Fatigue in Ultramarathon Athletes: A Comparison Between Laboratory and Real Race Settings.Diagnostics (Basel, Switzerland) · 2026Article
- Downhill Running-Induced Muscle Damage in Trail Runners: An Exploratory Study Regarding Training Background and Running Gait.Sports (Basel, Switzerland) · 2026Article
- Comparing full-body flywheel eccentric protocols: cluster set vs. traditional training on muscle damage, arterial stiffness, jump performance, grip strength, cognitive, and perceptual responses.Biology of sport · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo characterize the magnitude, timescale, and reliability of changes in functional and systemic outcome markers following moderate (MIR) and high (HIR) isoinertial resistance flywheel squat protocols (FSP).
methodsTwenty-four resistance-trained males completed two exercise trials (ET1 & ET2) separated by 32 days. Functional and systemic markers were assessed at pre-exercise (PRE), immediately post-exercise (IP), and 24 (24H), 48 (48H), and 72 (72H) hours post-exercise. Three-way group x trial x time repeated measures ANOVAs were conducted to compare all dependent variables between groups (MIR & HIR) and experimental trials across time. Test-retest reliability between trials was assessed using intraclass correlation coefficients (ICC).
resultsAt IP, both groups exhibited significantly decreased active range of motion, perceived recovery status, squat maximal voluntary isometric contraction force, and vertical jump performance, along with significantly increased muscle thickness and echo intensity (ultrasound), muscle soreness, and creatine kinase when compared to PRE. Most outcomes remained perturbed at 24H and 48H, especially in the HIR group. By 72H, only a subset of variables remained significantly changed from PRE. No significant attenuation of outcomes between trials were observed and test-retest reliability between trials was excellent for the FSP and moderate to excellent for most outcomes in both groups.
conclusionOur findings indicate that the FSP is a robust and repeatable exercise stimulus capable of eliciting significant exercise-induced muscle damage and reliable subsequent perturbations to functional and systemic markers of muscle damage. Our findings also support the use of crossover designs in future EIMD research designs with resistance-trained men.
Indexed as
Identifiers
39570364What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.