Evidence map›Paper›PMID 39570329›Full record

ReviewCurrent HIV/AIDS reports2024

Sex Differences in Metabolic Disorders of Aging and Obesity in People with HIV.

Jessica A Alvarez, Chin-An Yang, Victoria Ojuri, Kahsavyah Buckley, Brahmchetna Bedi, Joffi Musonge-Effoe, Adaiah Soibi-Harry, Cecile D Lahiri

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Navigating the Data Gaps of Ageing Among Women Living With HIV.Journal of the International AIDS Society · 2026
    Article
  4. Article
  5. Article
  6. Immuno-cell metabolic changes in HIV-1 infection.Infectious diseases & immunity · 2025
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica A AlvarezDepartment of Medicine, Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, GA, USA.
Chin-An YangLaney Graduate School, Emory University, Atlanta, GA, USA.
Victoria OjuriDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Kahsavyah BuckleyEmory University School of Medicine, Atlanta, GA, USA.
Brahmchetna BediDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Joffi Musonge-EffoeDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Adaiah Soibi-HarryDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Cecile D LahiriDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA. cdelill@emory.edu.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
J: NRSA Training CoreTL1TR002382 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Vasiliki Michopoulos · 2017 to 2026
$8.5M
SPPACE INSTI Study: Sex-specific Predictors, Pathways, And Cardiometabolic Effects of Weight Gain Associated with Integrase Strand-Transfer InhibitorsR01DK125246 · NIDDK · EMORY UNIVERSITY · PI ALVAREZ, JESSICA ALEJANDRA, LAHIRI, CECILE DELILLE · 2021 to 2025
$4.2M
NCATS NIH HHS TL1 TR002382NCATS NIH HHS UL1 TR002378NIAID NIH HHS P30 AI050409NIA NIH HHS U54 AG062334NIDDK NIH HHS R01 DK125246
6 · The paper itself

Abstract

purpose of reviewAs advances in antiretroviral therapy for people with HIV (PWH) have prolonged lifespans, prevalence of aging and obesity related metabolic disorders have increased. The purpose of this review is to summarize recent research assessing sex differences in metabolic disorders among PWH, including weight gain/obesity, steatotic liver disease, insulin resistance/diabetes, dyslipidemia, bone loss/osteoporosis, and sarcopenia. RECENT

findingsA growing body of evidence shows that women with HIV are at increased risk of developing metabolic disorders compared to men, including body weight gain and obesity, type 2 diabetes mellitus, dyslipidemia, bone loss, and sarcopenia, while men with HIV are at higher risk for hepatosteatosis and hepatic fibrosis. Future work should prioritize the adequate representation of women in HIV clinical studies. Understanding sex-specific mechanisms underlying metabolic dysfunction in PWH is imperative so that interventions can be developed to address a growing global epidemic of metabolic diseases.

Indexed as

AgingHIV InfectionsMetabolic DiseasesObesityFemaleHumansInsulin ResistanceMaleSarcopeniaSex FactorsAgingHIVMetabolicObesitySex differences

Identifiers

PMID39570329
PMCPMC11773452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.