Evidence map›Paper›PMID 39570295›Full record

ArticleMolecular biology reports2024

Moderate-intensity aerobic exercise inhibits cell pyroptosis to improve myocardial ischemia-reperfusion injury.

Yu Wang, Yushan Li, Chaofan Chen, Hailong Zhang, Weili Liu, Chao Wu, Haonan Chen, Ran Li, Jinghan Wang, Yingchao Shi and 2 more

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu Wang *Henan University People's Hospital, Zhengzhou, China.
Yushan Li *School of Physical Education, Henan University, Zhengzhou, China.
Chaofan ChenSchool of Physical Education, Henan University, Zhengzhou, China.
Hailong ZhangJoint National Laboratory for Antibody Drug Engineering, Schocolate of Medicine, Henan University, Kaifeng, China.
Weili LiuZhengzhou University Fuwai Central China Cardiovascular Hospital, Zhengzhou, China.
Chao WuSchool of Physical Education, Henan University, Zhengzhou, China.
Haonan ChenSchool of Physical Education, Henan University, Zhengzhou, China.
Ran LiSchool of Physical Education, Henan University, Zhengzhou, China.
Jinghan WangSchool of Physical Education, Henan University, Zhengzhou, China.
Yingchao ShiZhengzhou University Fuwai Central China Cardiovascular Hospital, Zhengzhou, China.
Shengfang WangZhengzhou University Fuwai Central China Cardiovascular Hospital, Zhengzhou, China.
Chuanyu GaoZhengzhou University Fuwai Central China Cardiovascular Hospital, Zhengzhou, China. gaocy6802@163.com.

Funding

Postdoctoral Foundation of Henan Provincial People's Hospital and Fuwei Huazhong Cardiovascular Disease Hospital ZCK2023064Postdoctoral Research Grant of Henan Province HN2024139Training Programme for Young Backbone Teachers in Higher Education Institutions in Henan Province 2024GGJS015Youth Natural Science Foundation of Henan Province 242300421516
6 · The paper itself

Abstract

backgroundMyocardial ischemia-reperfusion injury (MI/RI) significantly impacts the patients with acute myocardial infarction (AMI), with the NLRP3-mediated necrosis exacerbates the pathological progression of myocardial infarction. Exercise, recognized as a crucial approach for both disease prevention and treatment, is widely utilized in clinical practice worldwide and has demonstrated broad effectiveness in cardiovascular disease (CVD) prevention. PURPOSE: To explore the cardio protective effect of exercise preconditioning and the mechanism by which exercise modulation of NLRP3 improves myocardial ischemia and reperfusion injury. METHODS AND

resultsIn this study, C57BL/6 N mice were employed to establish an exercise preconditioning model and a MI/RI model. The exercise intervention involved moderate-intensity aerobic exercise on a treadmill (50-70% VO2max) for small animals. Our research findings indicate that moderate-intensity aerobic exercise intervention improved cardiac function, reduced myocardial injury and inflammatory response, decreased myocardial infarction area and degree of cell apoptosis in mice compared to those raised under conventional conditions. Additionally, the expression of NLRP3 in the myocardial tissue of mice with MI/RI was reduced after exercise intervention. Moreover, exercise inhibited the activation of apoptosis related proteins such as Caspase-1 and GSDMD, while reducing the levels of inflammatory factors such as IL-1β and IL-18.

conclusionsThis study found that moderate-intensity aerobic exercise can reduce the inflammatory response, reduce the degree of cell pyroptosis, reduce myocardial ischemia and reperfusion injury, and achieve endogenous protective effects on the myocardium.

Indexed as

Mice, Inbred C57BLMyocardial InfarctionMyocardial Reperfusion InjuryNLR Family, Pyrin Domain-Containing 3 ProteinPhysical Conditioning, AnimalPyroptosisAnimalsApoptosisCaspase 1Disease Models, AnimalInterleukin-18Interleukin-1betaMaleMiceMyocardiumCaspase 1Interleukin-18Interleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseModerate-intensity aerobic exerciseMyocardial ischemia-reperfusion injury (MI/RI)NLRP3 inflammasomePyroptosis

Identifiers

PMID39570295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.