Evidence map›Paper›PMID 39570281›Full record

Observational studyRevista medica del Instituto Mexicano del Seguro Social2024

[Electroencephalographic patterns and their association with functional prognosis in anti-NMDA autoimmune encephalitis].

Christian Alejandro Aguilar-Vázquez, Nallely Denisse Ruvalcaba-Sánchez, Julián Alberto Hernández-Domínguez, Sergio De Jesús Aguilar Castillo

Abstract readObservational StudyEnglish Abstract
In one paragraph

Observational study in Revista medica del Instituto Mexicano del Seguro Social, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Christian Alejandro Aguilar-VázquezInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Neurofisiología. Ciudad de México, México.ORCID 0000-0001-6400-2564
Nallely Denisse Ruvalcaba-SánchezInstituto Mexicano del Seguro Social, Hospital General de Zona No. 30, Servicio de Neurología. Ciudad de México, México.ORCID 0000-0002-5441-2647
Julián Alberto Hernández-DomínguezInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Neurología. Ciudad de México, México.ORCID 0000-0003-1028-6885
Sergio De Jesús Aguilar CastilloInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Neurofisiología. Ciudad de México, México.ORCID 0009-0006-5670-4324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Autoimmune encephalitis is a rare disease with low incidence and prevalence but carries high rates of disability and potential fatality. Objective: To determine whether the presence of abnormal electroencephalographic patterns in patients with anti-NMDAR autoimmune encephalitis affects functional prognosis at 3 months. Material and methods: A retrospective, observational, analytical, longitudinal-cross-sectional study was conducted with a retrospective cohort. Results: Out of a total of 44 patients with anti-NMDAR autoimmune encephalitis, concerning electroencephalographic findings, 19 patients had a normal EEG result (43.2%), 18 had cortical dysfunction (40.9%), 7 had epileptiform reports (15.9%), and only 1 had a Delta Brush report (2.3%). The functional outcome of patients at 3 months measured by the modified Rankin Scale (mRS) was as follows: 3 patients without disability (6.8%), 6 patients with mild disability (13.6%), 17 patients with mild to moderate disability (38.6%), 9 patients with moderate to severe disability (20.5%), 1 patient bedridden (2.3%), and 2 deceased (5.6%). Conclusion: In our study, no association was found between an abnormal electroencephalographic pattern and a worse functional prognosis at 3 months in patients with autoimmune encephalitis. Although the electroencephalogram analyzed is the initial one, it would be necessary to assess later whether the persistence of abnormalities in the electroencephalogram is related to a greater number of sequelae and disabilities.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisElectroencephalographyAdolescentAdultChildCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedPrognosisRetrospective StudiesYoung AdultAutoimmune Diseases of the Nervous SystemElectroencephalogramPrognosisReceptors, N-Methyl-D-Aspartate

Identifiers

PMID39570281
PMCPMC12520722

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.