Evidence map›Paper›PMID 39569765›Full record

ArticleJournal of viral hepatitis2025

Seroprevalence of Hepatitis C in Ethiopia: First National Study Based on the 2016 Ethiopian Demographic and Health Survey.

Getahun Molla Kassa, Atsbeha Gebreegziabxier Weldemariam, Saro Abdella Abrahim, Clare E French, Dawit Wolday, Emebet Dagne, Andargachew Mulu, Aynishet Adane, Sarah K Inglis, Andrew Radley and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of viral hepatitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Getahun Molla KassaPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-9926-7797
Atsbeha Gebreegziabxier WeldemariamEthiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID https://orcid.org/0000-0003-1987-6996
Saro Abdella AbrahimHealth Laboratory Services, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Clare E FrenchPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-6943-7353
Dawit WoldayEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Emebet DagneDepartment of Internal Medicine, Institute of Health, Jimma University, Jimma, Ethiopia.
Andargachew MuluArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Aynishet AdaneDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Sarah K InglisTayside Clinical Trials Unit, University of Dundee, Dundee, UK.
Andrew RadleyDivision of Public Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Geremew TasewEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Peter VickermanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-8291-5890
Elias Ali YesufDepartment of Health Policy and Management, Institute of Health, Jimma University, Jimma, Ethiopia.
Ora PaltielDepartment of Hematology and Braun School of Public Health, Hadassah-Hebrew University Faculty of Medicine, Jerusalem, Israel.
Mesay HailuEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Wondwossen AmogneDepartment of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
John F DillonDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
Matthew HickmanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0001-9864-459X
Aaron G LimPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Josephine G WalkerPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-9732-5738
DESTINE NIHR Global Health Research Group

Funding

NIHR NIHR133208Wellcome Trust
6 · The paper itself

Abstract

Hepatitis C virus (HCV) is hypothesised to be a public health problem in Ethiopia, and systematic review evidence suggested 1%-3% seroprevalence. We aimed to estimate the seroprevalence of HCV overall and across regions of Ethiopia. We estimated HCV seroprevalence using the 2016 Ethiopian Demographic and Health Survey (EDHS-2016). EDHS-2016 is a nationwide household survey conducted using two-stage cluster sampling methods. We tested all 26,753 samples from participating adult women (15-49 years) and men (15-59 years) using HCV Enzyme Immunoassay. Descriptive analyses were performed based on the Guide to Demographic Health Survey statistics. We applied sample weighting to derive representative estimates. Of the total tested, more than half (54.40%) were aged 15-29 years and 51.59% were women. Overall HCV seroprevalence was 0.18% (95% Confidence Interval: 0.10-0.32). Higher seroprevalences were found in Afar (0.92%) and South Nations Nationality Peoples Region (0.43%); people living with HIV (PLWH) (0.62%); the poorest wealth index (0.35%); people having multiple lifetime sexual partners (0.31%); and widowed/divorced individuals (0.30%). In stratified analyses by sex and residency, we found higher seroprevalences in non-Christian and non-Muslim males (1.98%) and rural population (1.00%), male PLWH (1.67%), rural PLWH (1.45%), widowed/divorced males (0.97%), and in all groups from the Afar region: males (1.30%), females (0.61%), urban (1.07%), and rural (0.86%). HCV seroprevalence among the general population in Ethiopia is much lower than from previous estimates. General population screening is unlikely to be cost-effective, and so screening programs targeted to people at greater risk of HCV will be required.

Indexed as

Hepatitis CAdolescentAdultCross-Sectional StudiesEthiopiaFemaleHealth SurveysHepacivirusHepatitis C AntibodiesHumansMaleMiddle AgedSeroepidemiologic StudiesYoung AdultHepatitis C AntibodiesEDHSEthiopiaHCVseroprevalencesurvey

Identifiers

PMID39569765
PMCPMC11883455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.