ArticleTurkish journal of pharmaceutical sciences2024
Longitudinal Evaluation of Developmental Protein Malnutrition Resembling Marasmic-Kwashiorkor Condition in Wistar Rats.
Article in Turkish journal of pharmaceutical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Animal models for understanding the mechanisms of malnutrition: a literature review.Frontiers in nutrition · 2025Review
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6 authors.
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Abstract
Objectives: Protein malnutrition (PMN) is a significant public health concern that can aggravate pathological states. The impact of early malnutrition on metabolism needs extensive evaluation. Current models employ short-term diet restriction and are neither ethically correct nor clinically relevant. This study aimed to develop a PMN rat model to evaluate the effects of a low-protein diet (LPD) on physiological, hematological, biochemical, and histological changes affected by malnourishment from postweaning to the 40 Materials and Methods: The PMN model was developed in Wistar rats (post-weaning) by assigning animals to patented LPD (10% protein) and a control group to a normal diet (18% protein). Developed model was confirmed by biometric, biochemcial parameters and Gomez classification of malnutrition. Results: LPD-induced PMN showed stunted growth, altered biochemical (albumin range, 1.9 - 2.4 g/dL, total protein range, 5.1 - 6.4 g/dL), and hematological markers mean corpuscular volume (52.03 ± 1.34, 47.45 ± 0.44, p≤0.01), mean corpuscular hemoglobin (17.67 ± 0.47, 15.37 ± 0.18, p≤0.001) and mean corpuscular haemoglobin concentration (33.87 ± 0.22, 32.37 ± 0.24, p≤0.001) and significantly affected hepatic histology. A long-term study was conducted to analyze the pattern of developmental PMN and its stabilization over time. Conclusion: The developed PMN rat model imitates clinical conditions and is confirmed as a stable, reproducible, and reliable model for short- and long-term studies. The clinical relevance of this approach opens new avenues for research in treatment, drug development, molecular interactions, and disease model development.
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