Evidence map›Paper›PMID 39569612›Full record

ArticleHistology and histopathology2025

Expression and prognostic value of PIM-1 kinase in gliomas.

Zelin Li, Hu Wang, Guangxiu Wang, Anling Zhang, Chen Wang, Lidong Mo, Zhifan Jia, Xiaoguang Tong

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Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zelin Li *Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, PR China.
Hu Wang *Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, PR China.
Guangxiu WangDepartment of Neurosurgery, Tianjin Medical University General Hospital. Tianjin Neurological Institute, Laboratory of Neuro-Oncology, Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, PR China.
Anling ZhangDepartment of Neurosurgery, Tianjin Medical University General Hospital. Tianjin Neurological Institute, Laboratory of Neuro-Oncology, Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, PR China.
Chen WangTianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, PR China.
Lidong MoTianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, PR China.
Zhifan JiaDepartment of Neurosurgery, Tianjin Medical University General Hospital. Tianjin Neurological Institute, Laboratory of Neuro-Oncology, Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, PR China.
Xiaoguang TongDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, PR China.

Funding

National Natural Science Foundation of China 30872985Science and technology project of Tianjin Health Commission MS20024
6 · The paper itself

Abstract

objectiveThis study aimed to explore the correlation of PIM-1 with the clinicopathological features and prognosis of patients.

methodsThe MTERF3 mRNA and protein expression levels in tissues were detected by western blot and immunohistochemistry. The expression and survival of PIM-1 in patients with glioma were analysed using the Gene Expression Profiling Interactive Analysis database, the Gene Expression Database of Normal and Tumor Tissues 2, and the Chinese Glioma Genome Atlas database. The relationship between PIM-1 expression and immune cells and chemokines was analysed using the Tumor Immune Estimation Resource Version 2.0 tool and the Tumor and Immune System Interactions Database. A Kaplan-Meier plot was used to estimate the correlation between PIM-1 expression and the survival of patients with glioma.

resultsThe expression of PIM-1 was upregulated in glioma and was positively correlated with tumour grade. The expression of PIM-1 was significantly inhibited on the second day after transfection (

conclusionPIM-1 is overexpressed in glioma and is related to the prognosis of glioblastoma multiforme, and PIM-1 may be a prognostic biomarker and therapeutic target for glioma.

Indexed as

Biomarkers, TumorBrain NeoplasmsGliomaProto-Oncogene Proteins c-pim-1AdultAgedFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisBiomarkers, TumorPIM1 protein, humanProto-Oncogene Proteins c-pim-1

Identifiers

PMID39569612

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