ArticleArteriosclerosis, thrombosis, and vascular biology2025
Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCerebral cavernous malformation (CCM) is a disease characterized by vascular malformations that primarily develop in the brain. These malformations are prone to leak, and their rupture or thrombotic closure can cause life-threatening hemorrhages and strokes. Mouse models have been instrumental to study the disease, but most cause premature lethality, precluding the investigation of disease mechanisms through intravital microscopy. Current mouse models also do not recapitulate human CCM skin lesions.
methodsEndothelial-specific deletion of
resultsWe report that human CCM skin lesions can be recapitulated in a mouse model and that skin lesions share hallmarks of CCM brain lesions. Intravital imaging reveals that CCM skin lesions are slow-flow malformations prone to thrombus formation.
conclusionsIntravital imaging of CCM skin lesions expands the toolkit of CCM research and allows longitudinal studies of lesion growth.
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