Evidence map›Paper›PMID 39569376›Full record

ArticleiScience2024

Utility of plasma suPAR to identify AKI and sepsis associated AKI in critically ill children.

Jing Xu, Jiao Chen, Min Li, Zhen Jiang, Fang Fang, Junlong Hu, Yueying Zhou, Huiwen Li, Zhenjiang Bai, Xiaozhong Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Research progress on biomarkers for acute kidney injury in children.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jing XuDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.
Jiao ChenPediatric Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.
Min LiPediatric Intensive Care Unit, Anhui Provincial Children's Hospital, Hefei, Anhui Province, P.R. China.
Zhen JiangPediatric Intensive Care Unit, Xuzhou Children's Hospital, Xuzhou, Jiangsu Province, P.R. China.
Fang FangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.
Junlong HuDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.
Yueying ZhouDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.
Huiwen LiDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.
Zhenjiang BaiPediatric Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.
Xiaozhong LiDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.
Guoping LuPediatric Intensive Care Unit, Children's Hospital of Fudan University, Shanghai, P.R. China.
Yanhong LiDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current biomarkers for sepsis-associated acute kidney injury (SA-AKI) lack specificity. The role of soluble urokinase plasminogen activator receptor (suPAR) in discriminating AKI and SA-AKI in children remains elusive. This prospective multicenter study was conducted in critically ill children cohorts using a derivation-validation design, and plasma samples were collected within first 24 h after admission. Plasma suPAR was independently associated with AKI, SA-AKI, and PICU mortality, even after adjustment for confounding variables. This multiclass classification model had the micro-average AUC of 0.89 with specificity of 97.6% for discriminating non-septic AKI, and specificity of 99.0% for discriminating SA-AKI, based on the cut-off values of 1.5 and 2.3-fold baseline in serum creatinine (SCr) and 4.5 and 11.2 ng/mL in plasma suPAR. The multiclass classification model provides the cutoffs for plasma suPAR and SCr and specifically discriminates critically ill children at high risk of non-septic AKI and SA-AKI, which can facilitate clinical utility.

Indexed as

Health sciencesInternal medicineMedical specialtyMedicineNephrology

Identifiers

PMID39569376
PMCPMC11576388

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.