Evidence map›Paper›PMID 39569374›Full record

ArticleiScience2024

Blood expression of NADK2 as a diagnostic biomarker for sciatica.

Xiaobo Wang, Zhenxiao Ren, Bingyu Wang, Jiawei Shi, Jingmin Liu, Yang Wang, Xin Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaobo WangDepartment of Spine Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhenxiao RenGuangdong Provincial Key Laboratory of Orthopaedics and Traumatology/Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Bingyu WangDepartment of Spine Surgery, The Affiliated TCM Hospital of Guangzhou Medical University, Guangzhou, China.
Jiawei ShiDepartment of Spine Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jingmin LiuDepartment of Spine Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yang WangDepartment of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xin ZhengDepartment of Spine Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sciatica is characterized by radiating pain along the sciatic nerve, with a lifetime prevalence of up to 43%. This study explored blood biomarkers for sciatica using transcriptomic microarray data (GSE124272 and GSE150408). Differential gene expression analysis identified NADK2 as a potential diagnostic biomarker. A diagnostic model based on NADK2 showed strong validation performance in 200 clinical cases. Gene set enrichment analysis (GSEA) suggested a connection between NADK2 and the aminoacyl-tRNA biosynthesis pathway. In conclusion, NADK2 emerges as promising diagnostic and therapeutic targets for sciatica, significantly advancing our comprehension of potential pathogenic mechanisms and offering perspectives for early diagnosis and treatment.

Indexed as

PathologyTranscriptomics

Identifiers

PMID39569374
PMCPMC11576402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.