Evidence map›Paper›PMID 39569372›Full record

ArticleiScience2024

The BNT162b2 mRNA vaccine demonstrates reduced age-associated T

Byron Brook, Abhinav Kumar Checkervarty, Soumik Barman, Cali Sweitzer, Anna-Nicole Bosco, Amy C Sherman, Lindsey R Baden, Elena Morrocchi, Guzman Sanchez-Schmitz, Paolo Palma and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Byron BrookPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Abhinav Kumar CheckervartyPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Soumik BarmanPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Cali SweitzerPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Anna-Nicole BoscoPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Amy C ShermanPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Lindsey R BadenDepartment of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Elena MorrocchiPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Guzman Sanchez-SchmitzPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Paolo PalmaResearch Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Etsuro NanishiPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Timothy R O'MearaPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Marisa E McGrathCenter for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Matthew B FriemanCenter for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Dheeraj SoniGlobal Investigative Toxicology, Preclinical Safety, Sanofi, Cambridge, MA 02142, USA.
Simon D van HarenPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Al OzonoffPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Joann Diray-ArcePrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Hanno SteenPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
David J DowlingPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Ofer LevyPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.

Funding

Small-molecule adjuvants to enhance the efficacy of flu vaccines in newborns and the elderly75N93019C00044 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2019 to 2023
$11.0M
Leveraging immunostimulatory pathways that enhance BCG vaccination for the rational design of synthetic neonatal vaccine formulationsR21AI137932 · NIAID · NORTHWESTERN UNIVERSITY · PI DOWLING, DAVID JAMES, SCOTT, EVAN ALEXANDER · 2019 to 2020
$468k
NIAID NIH HHS 75N93019C00044NIAID NIH HHS HHSN272201400052CNIAID NIH HHS HHSN272201800047CNIAID NIH HHS R21 AI137932
6 · The paper itself

Abstract

mRNA vaccines demonstrate impaired immunogenicity and durability in vulnerable older populations. We hypothesized that human

Indexed as

GeriatricsHealth sciencesImmunityImmunologyProteomics

Identifiers

PMID39569372
PMCPMC11576392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.