Evidence map›Paper›PMID 39569320›Full record

ArticleBioinformatics advances2024

MultiOmicsIntegrator: a nextflow pipeline for integrated omics analyses.

Bianka Alexandra Pasat, Eleftherios Pilalis, Katarzyna Mnich, Afshin Samali, Aristotelis Chatziioannou, Adrienne M Gorman

Abstract read
In one paragraph

Article in Bioinformatics advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Integrating multi-omics and machine learning for disease resistance prediction in legumes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bianka Alexandra PasatApoptosis Research Centre, School of Biological and Chemical Sciences, University of Galway, Galway H91TK33, Ireland.ORCID https://orcid.org/0009-0002-9511-4184
Eleftherios Pilalise-NIOS Applications PC, Athens 17671, Greece.
Katarzyna MnichApoptosis Research Centre, School of Biological and Chemical Sciences, University of Galway, Galway H91TK33, Ireland.
Afshin SamaliApoptosis Research Centre, School of Biological and Chemical Sciences, University of Galway, Galway H91TK33, Ireland.
Aristotelis ChatziioannouCenter of Systems Biology, Biomedical Reseach Foundation of the Academy of Athens, Athens 11527, Greece.
Adrienne M GormanApoptosis Research Centre, School of Biological and Chemical Sciences, University of Galway, Galway H91TK33, Ireland.ORCID https://orcid.org/0000-0002-6068-0058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: Analysis of gene and isoform expression levels is becoming critical for the detailed understanding of biochemical mechanisms. In addition, integrating RNA-seq data with other omics data types, such as proteomics and metabolomics, provides a strong approach for consolidating our understanding of biological processes across various organizational tiers, thus promoting the identification of potential therapeutic targets. Results: We present our pipeline, called MultiOmicsIntegrator (MOI), an inclusive pipeline for comprehensive omics analyses. MOI represents a unified approach that performs in-depth individual analyses of diverse omics. Specifically, exhaustive analysis of RNA-seq data at the level of genes, isoforms of genes, as well as miRNA is offered, coupled with functional annotation and structure prediction of these transcripts. Additionally, proteomics and metabolomics data are supported providing a holistic view of biological systems. Finally, MOI has tools to integrate simultaneously multiple and diverse omics datasets, with both data- and function-driven approaches, fostering a deeper understanding of intricate biological interactions. Availability and implementation: MOI and ReadTheDocs.

Identifiers

PMID39569320
PMCPMC11576358

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.