ArticleCureus2024
Efficacy of Dexamethasone in Reducing Postoperative Symptoms of the Surgical Extraction of Impacted Third Molars.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
introductionAmong anti-inflammatory medications, dexamethasone has an extended half-life and strong effects, particularly in oral surgical procedures. Administering dexamethasone helps reduce discomfort and inflammation and enhances recovery by minimizing postoperative complications. This study aimed to assess the effectiveness of dexamethasone administered before and after surgery in reducing postoperative pain and swelling and relieving mouth opening following the surgical removal of impacted third molars. MATERIAL AND
methodsAn observational, prospective cohort study was conducted on 60 patients who had already been administered with dexamethasone pre- and postoperatively and were divided into two non-randomized groups. The first group had received 8 mg of dexamethasone intramuscularly one hour before the surgical removal of impacted third molars, while the second group had received the same dose immediately after surgery. The observer evaluated pain, swelling, and mouth opening in both groups at baseline (preoperative) and on the second and seventh days after the surgical extraction of impacted third molars.
resultsIn terms of swelling, the second postoperative day showed a significant difference between the two groups (p<0.05). Group 2 exhibited more pronounced swelling (140.34±10.11 mm) than group 1 (127.50±13.29 mm), with a p-value of 0.006. Pain evaluation on the second day revealed that group 2 experienced notably higher levels of discomfort (3.60±0.99) than group 1 (3.33±0.98), with a p-value of 0.0463. While there was no significant variation in mouth opening before the operation (p=0.288), the second postoperative day showed a marked difference. Group 1 demonstrated a significantly less reduction in mouth opening (45.69±6.06 mm) than group 2 (38.69±4.40 mm), with a p-value of 0.001.
conclusionThe study has shown that administering dexamethasone before surgery led to better management of swelling, pain, and mouth opening after the procedure, compared to giving it postoperatively. These results supported the current clinical practice of utilizing corticosteroids prior to surgery to enhance patient outcomes following third molar extraction.
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