ArticleCureus2024
A Rare Presentation of Herpes Simplex Virus Encephalitis With Ischemic Stroke and Associated Acyclovir-Induced Acute Kidney Injury.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Unraveling Herpes Simplex Virus Encephalitis: Diagnosis and Management.Annals of African medicine · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This case report describes a 26-year-old female presenting with clinical features of encephalitis, which progressed to ischemic stroke. In addition, she was started on intravenous acyclovir 750 mg three times a day (TID, 10 mg/kg body weight every eight hours, recommended dose), which led to the development of an acute kidney injury (AKI). Subsequently, conservative management and a reduction in the dosage of acyclovir, followed by stopping it, led to the recovery of the patient's renal function. Three days after completely stopping the drug administration, she was continued on a reduced dose of intravenous acyclovir, completing a 10-day course, with improvement in overall condition with some residual right upper limb and lower limb weakness and slurring of speech. This case signifies the importance of presentation, timely management, and prevention of acyclovir-induced AKI; in addition, it also reports a less common complication of herpes simplex virus encephalitis (HSVE), which is ischemic stroke. The management of all these herpes simplex virus (HSV-1)-related complications in a single case will add much to the existing literature.
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