Evidence map›Paper›PMID 39569206›Full record

ArticlePatterns (New York, N.Y.)2024

RummaGEO: Automatic mining of human and mouse gene sets from GEO.

Giacomo B Marino, Daniel J B Clarke, Alexander Lachmann, Eden Z Deng, Avi Ma'ayan

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. The Common Fund Data Ecosystem (CFDE).bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Light and sex modifybioRxiv : the preprint server for biology · 2025
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Giacomo B MarinoMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Daniel J B ClarkeMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Alexander LachmannMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Eden Z DengMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Avi Ma'ayanMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Funding

The CFDE WorkbenchOT2OD036435 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI, SUBRAMANIAM, SHANKAR · 2023 to 2025
$7.2M
Proteogenomic translator for cancer biomarker discovery towards precision medicineU24CA271114 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Avi Ma'ayan, Pei Wang · 2022 to 2026
$5.0M
Elucidating the Molecular Mechanisms that Mediate DKD Progression in Patients Living with HIVR01DK131525 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI John Cijiang He, Avi Ma'ayan · 2022 to 2026
$4.2M
ARCHS4: Massive Mining of Publicly Available RNA Sequencing DataU24CA264250 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Avi Ma'ayan · 2022 to 2026
$4.1M
The LINCS DCIC Engagement Plan with the CFDEOT2OD030160 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI · 2020 to 2024
$3.4M
Diabetes Data and Hypothesis Hub (D2H2)RC2DK131995 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ATTIE, ALAN D, MA'AYAN, AVI · 2022 to 2023
$2.1M
NCI NIH HHS U24 CA264250NCI NIH HHS U24 CA271114NIDDK NIH HHS R01 DK131525NIDDK NIH HHS RC2 DK131995NIH HHS OT2 OD030160NIH HHS OT2 OD036435
6 · The paper itself

Abstract

The Gene Expression Omnibus (GEO) has millions of samples from thousands of studies. While users of GEO can search the metadata describing studies, there is a need for methods to search GEO at the data level. RummaGEO is a gene expression signature search engine for human and mouse RNA sequencing perturbation studies extracted from GEO. To develop RummaGEO, we automatically identified groups of samples and computed differential expressions to extract gene sets from each study. The contents of RummaGEO are served for gene set, PubMed, and metadata search. Next, we analyzed the contents of RummaGEO to identify patterns and perform global analyses. Overall, RummaGEO provides a resource that is enabling users to identify relevant GEO studies based on their own gene expression results. Users of RummaGEO can incorporate RummaGEO into their analysis workflows for integrative analyses and hypothesis generation.

Indexed as

ARCHS4CFDEdata integrationdata mininggene expressiongene set enrichment analysisLINCSRNA sequencingsignature searchtranscriptomics

Identifiers

PMID39569206
PMCPMC11573963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.