Evidence map›Paper›PMID 39569139›Full record

ArticlebioRxiv : the preprint server for biology2024

NetMedPy: A Python package for Large-Scale Network Medicine Screening.

Andrés Aldana, Michael Sebek, Gordana Ispirova, Rodrigo Dorantes-Gilardi, Albert-László Barabási, Joseph Loscalzo, Giulia Menichetti

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Andrés AldanaNetwork Science Institute, Northeastern University, 360 Huntington Ave, 02115, MA, USA.ORCID 0000-0001-9560-0380
Michael SebekNetwork Science Institute, Northeastern University, 360 Huntington Ave, 02115, MA, USA.ORCID 0000-0003-3347-7131
Gordana IspirovaChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Ave, 02115, MA, USA.ORCID 0009-0002-5254-9807
Rodrigo Dorantes-GilardiNetwork Science Institute, Northeastern University, 360 Huntington Ave, 02115, MA, USA.ORCID 0000-0002-6881-9077
Albert-László BarabásiNetwork Science Institute, Northeastern University, 360 Huntington Ave, 02115, MA, USA.ORCID 0000-0002-4028-3522
Joseph LoscalzoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Ave, 02115, MA, USA.ORCID 0000-0002-1153-8047
Giulia MenichettiNetwork Science Institute, Northeastern University, 360 Huntington Ave, 02115, MA, USA.ORCID 0000-0001-5201-6774

Funding

L-2-Hydroxyglutarate and Metabolic Remodeling in HypoxiaR01HL155107 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Joseph Loscalzo · 2021 to 2026
$4.1M
Branched-chain Keto-acids and Aerobic Glycolysis in Vascular Smooth Muscle CellsR01HL166137 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Joseph Loscalzo · 2023 to 2026
$2.8M
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertensionR01HL155096 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2021 to 2024
$1.6M
Methods for Unraveling the Impact of Dietary Xenobiotics on COPD Exacerbations with Multi-Dimensional NetworksK25HL173665 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Giulia Menichetti · 2024 to 2026
$487k
NHLBI NIH HHS K25 HL173665NHLBI NIH HHS R01 HL155096NHLBI NIH HHS R01 HL155107NHLBI NIH HHS R01 HL166137
6 · The paper itself

Abstract

Network medicine leverages the quantification of information flow within sub-cellular networks to elucidate disease etiology and comorbidity, as well as to predict drug efficacy and identify potential therapeutic targets. However, current Network Medicine toolsets often lack computationally efficient data processing pipelines that support diverse scoring functions, network distance metrics, and null models. These limitations hamper their application in large-scale molecular screening, hypothesis testing, and ensemble modeling. To address these challenges, we introduce NetMedPy, a highly efficient and versatile computational package designed for comprehensive Network Medicine analyses.

Identifiers

PMID39569139
PMCPMC11577252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.