Evidence map›Paper›PMID 39569070›Full record

ArticleFrontiers in cellular neuroscience2024

A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex.

Kaijie Ma, Daoqi Zhang, Kylee McDaniel, Maria Webb, Samuel S Newton, Francis S Lee, Luye Qin

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaijie MaDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
Daoqi ZhangDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
Kylee McDanielDepartment of Biotechnology, Mount Marty University, Yankton, SD, United States.
Maria WebbSchool of Health Sciences, University of South Dakota, Vermillion, SD, United States.
Samuel S NewtonDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
Francis S LeeDepartment of Psychiatry, Department of Pharmacology, Sackler Institute for Developmental Psychobiology, Weill Cornell Medicine, New York, NY, United States.
Luye QinDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.

Funding

Wichozani-A Healthy Lifestyle for Rural American Indian Youth through Cultural and Physical Activities: A Community-Based Participatory Research StudyP20GM103443 · NIGMS · UNIVERSITY OF SOUTH DAKOTA · PI Victor Chester Huber · 2012 to 2026
$58.1M
Trophic Factors in CognitionR01MH106640 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SATHYANESAN, SAMUEL NEWTON · 2016 to 2025
$3.7M
Impact of BDNF on the Development of Social Behavior CircuitsR01MH123154 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEE, FRANCIS SANG YONG, LISTON, CONOR M · 2020 to 2024
$3.0M
Neural mechanisms of ASH1L in autism spectrum disorderR21MH134106 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI QIN, LUYE · 2023 to 2023
$411k
NIGMS NIH HHS P20 GM103443NIMH NIH HHS R01 MH106640NIMH NIH HHS R01 MH123154NIMH NIH HHS R21 MH134106
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with strong genetic heterogeneity and more prevalent in males than females. We and others hypothesize that diminished activity-dependent neural signaling is a common molecular pathway dysregulated in ASD caused by diverse genetic mutations. Brain-derived neurotrophic factor (BDNF) is a key growth factor mediating activity-dependent neural signaling in the brain. A common single nucleotide polymorphism (SNP) in the pro-domain of the human

Indexed as

activity-dependent neural signalingBDNFintrinsic neuronal excitabilitysexVal66Met polymorphism

Identifiers

PMID39569070
PMCPMC11576208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.