ArticleJournal of obstetrics and gynaecology of India2024
Evaluation of NKT Cell Percentage and Function and Its Relationship with Serum IFN-γ and Vitamin D Levels in Women with Recurrent Spontaneous Abortion and Recurrent Implantation Failure.
Article in Journal of obstetrics and gynaecology of India, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mothers experiencing recurrent spontaneous abortion (RSA) along with repeated implantation failures (RIF) could potentially have abnormalities in their immune systems. Vitamin D is known as a crucial immunomodulatory agent. This study aimed to assess the ratio of Natural Killer T-cells (NKTs) and the correlation between this ratio with serum vitamin D levels among women with RSA and RIF. Methods: In this research, blood samples were collected from both patients and a group of healthy individuals. The flow cytometry technique was used to determine the proportion of NKT and activated NKT cells. Additionally, Vitamin D and IFN-γ levels were measured using the ELISA technique. Results: The mean ratio of NKT cells and IFN-γ levels increased significantly in those women with RSA relative to our healthy control group [( Conclusions: It was found that increasing ratio as well as inflammatory activity of NKT cells correlated with repeated miscarriage. Reduced vitamin D levels could cause immune system disorder along with pregnancy complications.
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