ArticleHeliyon2024
Frequency-dependent effects of superimposed NMES on spinal excitability in upper and lower limb muscles.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intersegmental Modulation of Lower-Limb Corticospinal Excitability and Inhibition Induced by Upper-Limb Isometric Contractions: A Systematic Review.The European journal of neuroscience · 2026Pooled it
- The effectiveness of 6-week superimposed neuromuscular electrical stimulation in knee osteoarthritis: an assessor blinded randomized controlled clinical trial.Archives of orthopaedic and trauma surgery · 2025Trial
- Acute modulation of common synaptic inputs and motor unit discharge rates following neuromuscular electrical stimulation superimposed onto voluntary contractions.Frontiers in physiology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superimposing neuromuscular electrical stimulation (NMES) on voluntary contractions has proven to be highly effective for improving muscle strength and performance. These improvements might involve specific adaptations occurring at cortical and spinal level. The effects of NMES on corticospinal activation seem to be frequency dependent and differ between upper and lower limb muscles. The aim of this study was to investigate acute responses in spinal excitability, as measured by H-reflex amplitude of flexor carpi radialis (FCR) and soleus (SOL) muscles, after NMES superimposed on voluntary contractions (NMES + ISO) at two different pulse frequencies (40 and 80 Hz). Conditions involved fifteen intermittent contractions at submaximal level. Before and after each condition, H-reflexes were elicited in FCR and SOL muscles. H-reflex amplitudes increased in FCR and SOL following both NMES + ISO at 40 and 80 Hz. The potentiation of the H-reflex was greater following the 40 Hz condition compared to 80 Hz, although no differences between muscles emerged. These findings indicated that superimposing NMES has an excitatory effect on spinal motoneurons in both upper and lower limb muscles with an overall greater response after low frequency NMES. Such facilitation could be associated to enhanced somatosensory stimuli conjunctly with higher supraspinal downward commands.
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Registered trials
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