Evidence map›Paper›PMID 39568799›Full record

ArticleJournal of developmental and physical disabilities2024

Social and language regression: characteristics of children with autism spectrum disorder in a community-based sample.

Nuri Reyes, Gnakub Norbert Soke, Lisa Wiggins, Brian Barger, Eric Moody, Cordelia Rosenberg, Laura Schieve, Judith Reaven, Ann M Reynolds, Susan Hepburn

Abstract read
In one paragraph

Article in Journal of developmental and physical disabilities, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Defining and Measuring Developmental Regression During Childhood: A Scoping Review.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nuri ReyesSchool of Medicine, University of Colorado-Anschutz Medical Campus, 13121 E. 17th Ave, 80045 Aurora, CO, USA.
Gnakub Norbert SokeNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lisa WigginsNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Brian BargerCenter for Leadership in Disability, School of Public Health, Georgia State University, Atlanta, GA, USA.
Eric MoodyInstitute for Disabilities, University of Wyoming, Laramie, WY, USA.
Cordelia RosenbergSchool of Medicine, University of Colorado-Anschutz Medical Campus, 13121 E. 17th Ave, 80045 Aurora, CO, USA.
Laura SchieveNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Judith ReavenSchool of Medicine, University of Colorado-Anschutz Medical Campus, 13121 E. 17th Ave, 80045 Aurora, CO, USA.
Ann M ReynoldsSchool of Medicine, University of Colorado-Anschutz Medical Campus, 13121 E. 17th Ave, 80045 Aurora, CO, USA.
Susan HepburnDepartments of Human Development & Family Studies, Colorado State University, Fort Collins, CO, USA.

Funding

Colorado CADDRE Study to Explore Early Development CADDRE_SEED IIU01DD000750 · DD · UNIVERSITY OF COLORADO DENVER · PI ROBINSON, CORDELIA · 2011 to 2015
$5.1M
Component A: CADDRE: Study to Explore Early Development (SEED) 3U01DD001210 · DD · UNIVERSITY OF COLORADO DENVER · PI ROBINSON, CORDELIA · 2016 to 2020
$3.8M
Intramural CDC HHS CC999999NCBDD CDC HHS U01 DD000750NCBDD CDC HHS U01 DD001210
6 · The paper itself

Abstract

This study investigated the prevalence, and the developmental, behavior and emotional outcomes of 675 preschoolers with ASD with or without a history of regression, who participated in the Study to Explore Early Development (SEED). The SEED project is a cross-sectional case-control study that collected data between 2007 and 2011. Children's history of regression, adaptive skills, and behavior problems were assessed using the Autism Diagnostic Interview-Revised (ADI-R), the Vineland Adaptive Behavior Scales-Second Edition (Vineland-2), and the Child Behavior Checklist (CBCL), respectively; and children's developmental levels were assessed using the Mullen Scales of Learning (MSEL). Findings from this study indicated that 26% of children experienced social and language regression, and of those with regression, 76% had regained lost skills upon completion of the study. Compared to children without a history of regression, children with social regression demonstrated increased internalizing problems and decreased fine motor skills, and children with language regression demonstrated poorer language skills. Also, children with language and social regression displayed poorer adaptive communication skills than children without regression. Children who experienced regression in one area of development demonstrated better outcomes than those who experience regression in multiple areas. To conclude, children with regression are at risk for poorer outcomes during their preschool years.

Indexed as

Language and social regressionOutcomesPreschoolers with autism

Identifiers

PMID39568799
PMCPMC11578110

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.