ArticleEClinicalMedicine2024
Exploring the genetics of airflow limitation in lung function across the lifespan - a polygenic risk score study.
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Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed.
- Article
- Longitudinal protein profiling of blood during childhood into early adulthood.Nature communications · 2026Article
- Long-term exposure to air pollution and metabolites in children and young adults in a Swedish birth cohort.Journal of exposure science & environmental epidemiology · 2026Article
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
- Treatment of chronic obstructive pulmonary disease: current pipeline and new opportunities.Nature reviews. Drug discovery · 2026Review
- Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts.ERJ open research · 2025Article
- Association of Physical Frailty With Incidence and Life Expectancy of COPD: A Population-Based Cohort Study.Chest · 2025Article
- Longitudinal study of the influence of obesity, C-reactive protein, and smoking on FEV1 decline in young adulthood.BMC pulmonary medicine · 2025Observational
- Importance of allergic sensitisation for normal range of fractional exhaled nitric oxide in adolescents.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- The impact of child and adolescent health on adult respiratory health: the evidence, gaps and priorities.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Towards early detection and disease interception of COPD across the lifespan.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Article
- Contrasting the clinical and biological characteristics of young and old COPD patients.ERJ open research · 2025Article
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Authors and funding
56 authors.
Natalia Hernandez-PachecoDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
Anna KilanowskiInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Campus Neuherberg, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Ashish KumarDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
John A CurtinDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Cobbett House Manchester Royal Infirmary, Oxford Rd, Manchester, M13 9WL, United Kingdom.
Núria OlveraCIBER de Enfermedades Respiratorias (CIBERES), Spain.
Sara KressIUF - Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225, Düsseldorf, Germany.
Xander BertelsDepartment of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
Lies LahousseDepartment of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.
Laxmi BhattaK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Håkon Jarls gt.11, 7491, Trondheim, Norway.
Raquel GranellMedical Research Council Integrative Epidemiology Unit (MRC-IEU), Population Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, 5 Tyndall Ave, Bristol, BS8 1UD, United Kingdom.
Sergi MaríBiobizkaia Health Research Institute, University of the Basque Country (UPV/EHU), Leioa, 48940, Bizkaia, Spain.
Jose Ramon BilbaoBiobizkaia Health Research Institute, University of the Basque Country (UPV/EHU), Leioa, 48940, Bizkaia, Spain.
Yidan SunUniversity of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Casper-Emil Tingskov PedersenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Ledreborg alle 34, 2820, Gentofte, Denmark.
Tarik KarramassThe Generation R Study Group, Erasmus MC, University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
Elisabeth ThieringInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Campus Neuherberg, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Christina DardaniMedical Research Council Integrative Epidemiology Unit (MRC-IEU), Population Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, 5 Tyndall Ave, Bristol, BS8 1UD, United Kingdom.
Simon Kebede MeridDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
Gang WangDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
Jenny HallbergDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
Sarah KochISGlobal, Barcelona, Spain.
Judith Garcia-AymerichISGlobal, Barcelona, Spain.
Ana EspluguesCIBER Epidemiología y Salud Pública (CIBERESP), Spain.
Maties TorrentIb-Salut, Area de Salut de Menorca, Palma, Spain.
Jesus IbarluzeaCIBER Diabetes y Enfermedades Metabólicas asociadas (CIBEDEM), Spain.
Lesley LoweDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Cobbett House Manchester Royal Infirmary, Oxford Rd, Manchester, M13 9WL, United Kingdom.
Angela SimpsonDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Cobbett House Manchester Royal Infirmary, Oxford Rd, Manchester, M13 9WL, United Kingdom.
Ulrike GehringInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Roel C H VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Graham RobertsDavid Hide Asthma and Allergy Research Centre, St Marys Hospital Nhs Trust, Newport, PO30 5TG, United Kingdom.
Anna BergströmInstitute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, 171 65, Solna, Stockholm, Sweden.
Judith M VonkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
Liesbeth DuijtsThe Generation R Study Group, Erasmus MC, University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Ledreborg alle 34, 2820, Gentofte, Denmark.
Nic TimpsonMedical Research Council Integrative Epidemiology Unit (MRC-IEU), Population Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, 5 Tyndall Ave, Bristol, BS8 1UD, United Kingdom.
Guy BrusselleDepartment of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Ben M BrumptonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Håkon Jarls gt.11, 7491, Trondheim, Norway.
Arnulf LanghammerDepartment of Levanger Hospital, Nord-Trøndelag Hospital Trust, Helse Nord-Trøndelag, 7601, Levanger, Norway.
Stephen TurnerRoyal Aberdeen Children's Hospital NHS Grampian, Westburn Rd, Aberdeen, AB25 2ZG, United Kingdom.
John W HollowayNIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, United Kingdom.
Syed Hasan ArshadDavid Hide Asthma and Allergy Research Centre, St Marys Hospital Nhs Trust, Newport, PO30 5TG, United Kingdom.
Anhar UllahNational Heart and Lung Institute, Imperial College London, St Mary's Campus Medical School, Norfolk Place, London W2 1PG, United Kingdom.
Adnan CustovicNational Heart and Lung Institute, Imperial College London, St Mary's Campus Medical School, Norfolk Place, London W2 1PG, United Kingdom.
Paul CullinanNational Heart and Lung Institute, Imperial College London, St Mary's Campus Medical School, Norfolk Place, London W2 1PG, United Kingdom.
Clare S MurrayDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Cobbett House Manchester Royal Infirmary, Oxford Rd, Manchester, M13 9WL, United Kingdom.
Maarten van den BergeUniversity of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Inger KullDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
Tamara SchikowskiIUF - Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225, Düsseldorf, Germany.
Jadwiga A WedzichaNational Heart and Lung Institute, Imperial College London, St Mary's Campus Medical School, Norfolk Place, London W2 1PG, United Kingdom.
Gerard KoppelmanUniversity of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Rosa FanerCIBER de Enfermedades Respiratorias (CIBERES), Spain.
Àlvar AgustíCIBER de Enfermedades Respiratorias (CIBERES), Spain.
Marie StandlInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Campus Neuherberg, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Erik MelénDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
CADSET Clinical Research Collaboration of the European Respiratory Society
Funding
Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2MEpidemiology of asthma: risk and prognosis in a cohort from birth to adolescenceR01HL082925 · NHLBI · ST. MARY'S HOSPITAL NEWPORT · PI ARSHAD, SYED HASAN · 2007 to 2010
$1.7MNHLBI NIH HHS R01 HL082925NIAID NIH HHS R01 AI121226Wellcome Trust
Abstract
Background: Chronic obstructive pulmonary disease (COPD) is caused by interactions between many factors across the life course, including genetics. A proportion of COPD may be due to reduced lung growth in childhood. We hypothesized that a polygenic risk score (PRS) for COPD is associated with lower lung function already in childhood and up to adulthood. Methods: A weighted PRS was calculated based on the 82 association signals ( Findings: We found significant associations between the PRS for airflow limitation and: Interpretation: We provide evidence that a higher genetic risk for COPD is linked to lower lung function from childhood onwards. Funding: This study was supported by CADSET, a Clinical Research Collaboration of the European Respiratory Society.
Indexed as
Chronic obstructive pulmonary diseaseGeneticsLung functionPolygenic risk score
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