ArticleFrontiers in medicine2024
Association between life's essential 8 and hyperuricemia among adults in the United States: insights from NHANES 2005-2018.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Association between Life's Essential 8 and hyperuricemia in the Chinese elderly.Asia Pacific journal of clinical nutrition · 2025Article
- Adherence to Life's Essential 8 is associated with lower risk of hyperuricemia among adults in Beijing, China.Frontiers in nutrition · 2025Article
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Authors and funding
2 authors.
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Abstract
Background: Hyperuricemia is a significant risk factor for various metabolic and cardiovascular conditions. Life's Essential 8 (LE8), a comprehensive measure of cardiovascular health promoted by the American Heart Association, may have a protective role against hyperuricemia. This study aims to evaluate the association between LE8 scores and hyperuricemia in a representative sample of US adults. Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2018, encompassing 26,885 adults. LE8 scores were calculated based on diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. Hyperuricemia was defined as serum uric acid levels ≥7.0 mg/dL in men and ≥ 6.0 mg/dL in women. Logistic regression and generalized additive models (GAMs) were used to analyze the relationship between LE8 scores and hyperuricemia, adjusting for potential confounders. Results: Higher LE8 scores were significantly associated with lower odds of hyperuricemia (OR per 10-point increase: 0.73, 95% CI: 0.72-0.75, Conclusion: The findings suggest that higher LE8 scores are robustly associated with lower odds of hyperuricemia in US adults. These results support the promotion of comprehensive cardiovascular health behaviors encapsulated by LE8 to mitigate hyperuricemia risk. Further studies are needed to explore the causal pathways and potential interventions.
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