Evidence map›Paper›PMID 39568643›Full record

ArticlePatterns (New York, N.Y.)2024

Generating realistic neurophysiological time series with denoising diffusion probabilistic models.

Julius Vetter, Jakob H Macke, Richard Gao

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julius VetterMachine Learning in Science, University of Tübingen and Tübingen AI Center, Tübingen, Germany.
Jakob H MackeMachine Learning in Science, University of Tübingen and Tübingen AI Center, Tübingen, Germany.
Richard GaoMachine Learning in Science, University of Tübingen and Tübingen AI Center, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Denoising diffusion probabilistic models (DDPMs) have recently been shown to accurately generate complicated data such as images, audio, or time series. Experimental and clinical neuroscience also stand to benefit from this progress, as the accurate generation of neurophysiological time series can enable or improve many neuroscientific applications. Here, we present a flexible DDPM-based method for modeling multichannel, densely sampled neurophysiological recordings. DDPMs can generate realistic synthetic data for a variety of datasets from different species and recording techniques. The generated data capture important statistics, such as frequency spectra and phase-amplitude coupling, as well as fine-grained features such as sharp wave ripples. Furthermore, data can be generated based on additional information such as experimental conditions. We demonstrate the flexibility of DDPMs in several applications, including brain-state classification and missing-data imputation. In summary, DDPMs can serve as accurate generative models of neurophysiological recordings and have broad utility in the probabilistic generation of synthetic recordings for neuroscientific applications.

Indexed as

computational neurosciencediffusion modelsgenerative modelingmachine learningneurophysiological recordings

Identifiers

PMID39568643
PMCPMC11573898

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.