Evidence map›Paper›PMID 39568326›Full record

ArticleEpigenomics

SNHG12 in cancer-associated fibroblast-derived extracellular vesicle induces macrophage-myofibroblast transition.

Tao Wu, Li Zeng, Chao Peng, Zheng Zhao, Weihao Mu, Song Wang, Deli Tan

Abstract read
In one paragraph

Article in Epigenomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tao WuCardiothoracic surgery department, Banan Hospital of Chongqing medical university, Chongqing, China.
Li ZengDepartment of Pathology, Chongqing Ninth People's Hospital, Chongqing, China.
Chao PengDepartment of Thoracic surgery, Chongqing Ninth People's Hospital, Chongqing, China.
Zheng ZhaoDepartment of Thoracic surgery, Chongqing Ninth People's Hospital, Chongqing, China.
Weihao MuDepartment of Thoracic surgery, Chongqing Ninth People's Hospital, Chongqing, China.
Song WangDepartment of Thoracic surgery, Chongqing Ninth People's Hospital, Chongqing, China.
Deli TanDepartment of Thoracic surgery, Chongqing Ninth People's Hospital, Chongqing, China.ORCID 0009-0004-6775-8841

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate mechanism of lncRNA SNHG12 induced macrophage-myofibroblast transition (MMT) in cancer-associated fibroblasts (CAFs)-derived extracellular vesicles (EVs) in non-small cell lung cancer (NSCLC).

methodCAFs EVs were isolated from human NSCLC tissue and adjacent cancerous tissue (

resultLncRNA SNHG12 derived from CAFs-EVs promoted the transformation of M2 macrophages into MMT. In addition, lncRNA-SNHG12 increased the expression of Smad3 which was significantly upregulated in MMT through sponge of miR-181a-5p.

conclusionLncRNA SNHG12 derived from CAFs-EV induced MMT in NSCLC.

Indexed as

Cancer-Associated FibroblastsCarcinoma, Non-Small-Cell LungExtracellular VesiclesLung NeoplasmsMacrophagesMicroRNAsMyofibroblastsRNA, Long NoncodingSmad3 ProteinCell Line, TumorGene Expression Regulation, NeoplasticHumansMicroRNAsRNA, Long NoncodingSmad3 ProteinSMAD3 protein, humanSNHG12 long non-coding RNA, humanCAFs-EVslncRNA SNHG12MacrophagesmiR-181a-5pMMTNSCLCSmad3

Identifiers

PMID39568326
PMCPMC11622769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.