ReviewSystematic reviews2024
Barriers and facilitators to enrollment in pediatric clinical trials: an overview of systematic reviews.
Review in Systematic reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Smaller hamstrings autograft size after primary ACL reconstruction is associated with higher odds for graft failure: A meta-analysis on autografts sizes covering 46,268 patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Pooled it
- Acceptability and Feasibility of an Educational Intervention to Improve Researcher-Participant Interactions in a Neonatal Intensive Care Unit Clinical Trial: Research Team Feedback on the BRIEF Intervention.American journal of perinatology · 2026Trial
- Sleep Management and Recovery After TBI in Kids (SMART-Kids): Pilot Trial Using Melatonin.Hospital pediatrics · 2026Article
- The Impact of Clinical Trial Participation on Quality of Life in Duchenne Muscular Dystrophy.Pharmaceutical medicine · 2026Article
- Expertise of European Clinical Trial Units in Conducting and Managing Cross-Border Pediatric Clinical Trials for Rare Diseases.Therapeutic innovation & regulatory science · 2026Article
- Informed Consent for Pediatric Lyme Meningitis Study: In-Person Versus Remote Approach.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- Determinants of Infant Participation and Non-Participation in Primary Prevention Trials.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2026Article
- Comparing in-person and online recruitment methods in a prospective pediatric cohort study.Pediatric research · 2026Article
- Parental perspectives and willingness towards digital paediatric research: a cross-sectional survey in two Chinese cities.BMJ open · 2026Article
- Recruiting children and young people with vision impairment for clinical research - experience from the SeeMyLife study.BMC medical research methodology · 2026Article
- Mobile Vaccine Uptake (MoVeUP): a randomized effectiveness trial for a vaccine communication app.Vaccine: X · 2026Article
- Developmental candidate GHP-88310/EIDD-3608 with high tolerability and oral efficacy in measles and respiratory paramyxovirus models.Science advances · 2026Article
- Guardian Presence in Research Conducted on Children With Blunt Abdominal Trauma in the Emergency Department.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- Disparities in Headache Care and Research in Children and Adolescents: A Narrative Review.Current pain and headache reports · 2026Review
- Trial Enrollment Correlates in an HIV Status-Neutral mHealth Intervention Among Young Black and Latinx Men and Transgender Women Who have Sex with Men.AIDS and behavior · 2026Article
- Cross-border access to clinical trials: participation of pediatric patients and language inclusion.Pediatric research · 2026Article
- Age-dependent Dynamics of the Electrocardiographic Parameters in Cardiovascular Disease-Free Children.medRxiv : the preprint server for health sciences · 2026Article
- Implementation of Online Mindfulness With Peer Mentoring for Parent and Sibling Carers of People With Intellectual and Developmental Disabilities.Journal of intellectual disability research : JIDR · 2026Article
- Caregiver decision-making on pediatric research participation in congenital heart disease in western China: a qualitative study.Frontiers in public health · 2026Article
- Off-label prescribing in Italian pediatric practice: insights from a nationwide survey.European journal of pediatrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecruiting a sufficient number of patients is often a challenge for conducting clinical trials. Published data reveal that only 10% of eligible patients according to inclusion and exclusion criteria are enrolled in clinical trials. Consequentially, identifying barriers and facilitators may improve enrollment. These factors may differ in the pediatric population, for example, due to the involvement of parents in the decision-making process. We aimed to conduct an overview of systematic reviews to summarize the barriers and facilitators influencing the enrollment of pediatric participants in clinical trials.
methodsA systematic literature search in PubMed and Epistemonikos of published systematic reviews focusing on barriers and facilitators influencing the enrollment of pediatric patients in clinical trials was conducted. Study selection, data extraction, and quality assessment were performed by two authors independently. The methodological quality was judged using a critical appraisal tool. Finally, data were narratively synthesized.
resultsOf 283 identified systematic reviews, four met the inclusion criteria and were included in the overview. Parents belonging to an ethnic minority or having low socioeconomic status were identified as barriers to enrollment whereas higher parental education and higher age served as facilitators. Additionally, existing expectations, previous treatment experiences and preferences, study duration, type of control group, and the child's attitude toward study participation could favor or hinder participation. Furthermore, physicians' opinions of study-related treatments may also influence the enrollment process.
conclusionThis overview provides a summary of barriers and facilitators to the enrollment of pediatric patients in clinical trials. Taking into account this information may enhance the enrollment of this hard-to-reach population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.